Assay Detail
ADMET
CHEMBL4257180
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Inhibition of CYP3A4 (unknown origin)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Novel cytochrome p450 inhibitors and their method of use
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.97 | 6.61 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4126284 | — | — | 1 | 6.61 |
| CHEMBL4126996 | — | — | 1 | 6.20 |
| CHEMBL4129721 | — | — | 1 | 6.16 |
| CHEMBL4288256 | — | — | 1 | 6.06 |
| CHEMBL4291002 | — | — | 1 | 5.78 |
| CHEMBL4128368 | — | — | 1 | 5.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4126284 | — | IC50 | = | 243.0 | nM | 6.61 |
| CHEMBL4126996 | — | IC50 | = | 636.0 | nM | 6.20 |
| CHEMBL4129721 | — | IC50 | = | 695.0 | nM | 6.16 |
| CHEMBL4288256 | — | IC50 | = | 873.0 | nM | 6.06 |
| CHEMBL4291002 | — | IC50 | = | 1670.0 | nM | 5.78 |
| CHEMBL4128368 | — | IC50 | = | 9360.0 | nM | 5.03 |