Assay Detail
Binding
CHEMBL4258539
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Inhibition of equine serum BuChE using S-butyrylthiocholine iodide as substrate pretreated for 10 mins followed by substrate addition and measured after 10 mins by Ellman's method
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Equus caballus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and evaluation of indole derivatives as multifunctional agents against Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.49 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL255231 | LADOSTIGIL | 2.0 | 1 | 5.70 |
| CHEMBL4290661 | — | — | 1 | 5.64 |
| CHEMBL4280184 | — | — | 1 | 5.55 |
| CHEMBL4278916 | — | — | 1 | 5.52 |
| CHEMBL4280019 | — | — | 1 | 5.50 |
| CHEMBL4284601 | — | — | 1 | 5.46 |
| CHEMBL4288413 | — | — | 1 | 5.40 |
| CHEMBL4294875 | — | — | 1 | 5.34 |
| CHEMBL4286834 | — | — | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL255231 | LADOSTIGIL | IC50 | = | 1980.0 | nM | 5.70 |
| CHEMBL4290661 | — | IC50 | = | 2290.0 | nM | 5.64 |
| CHEMBL4280184 | — | IC50 | = | 2820.0 | nM | 5.55 |
| CHEMBL4278916 | — | IC50 | = | 3010.0 | nM | 5.52 |
| CHEMBL4280019 | — | IC50 | = | 3180.0 | nM | 5.50 |
| CHEMBL4284601 | — | IC50 | = | 3480.0 | nM | 5.46 |
| CHEMBL4288413 | — | IC50 | = | 3960.0 | nM | 5.40 |
| CHEMBL4294875 | — | IC50 | = | 4550.0 | nM | 5.34 |
| CHEMBL4286834 | — | IC50 | = | 5010.0 | nM | 5.30 |