Assay Detail
Functional
CHEMBL4259805
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Identification of potent catalytic inhibitors of human DNA topoisomerase II by structure-based virtual screening.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 38 | 4.80 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4287101 | — | — | 1 | 6.00 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 5.96 |
| CHEMBL4280052 | — | — | 1 | 5.75 |
| CHEMBL1709376 | — | — | 1 | 5.00 |
| CHEMBL4283977 | — | — | 1 | 4.96 |
| CHEMBL4285717 | — | — | 1 | 4.50 |
| CHEMBL4283627 | — | — | 1 | 4.43 |
| CHEMBL4285482 | — | — | 1 | 4.34 |
| CHEMBL2170108 | — | — | 1 | 4.27 |
| CHEMBL4290522 | — | — | 1 | 4.24 |
| CHEMBL4291901 | — | — | 1 | 4.11 |
| CHEMBL4293926 | — | — | 1 | 4.01 |
| CHEMBL4286684 | — | — | 1 | - |
| CHEMBL4283334 | — | — | 1 | - |
| CHEMBL1451226 | — | — | 1 | - |
| CHEMBL4278165 | — | — | 1 | - |
| CHEMBL4294027 | — | — | 1 | - |
| CHEMBL4280175 | — | — | 1 | - |
| CHEMBL1529748 | — | — | 1 | - |
| CHEMBL4295028 | — | — | 1 | - |
| CHEMBL4294214 | — | — | 1 | - |
| CHEMBL4284048 | — | — | 1 | - |
| CHEMBL4276745 | — | — | 1 | - |
| CHEMBL4285122 | — | — | 1 | - |
| CHEMBL4277171 | — | — | 1 | - |
| CHEMBL4292989 | — | — | 1 | - |
| CHEMBL259761 | — | — | 1 | - |
| CHEMBL4289111 | — | — | 1 | - |
| CHEMBL4278444 | — | — | 1 | - |
| CHEMBL4278849 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4287101 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4280052 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL1709376 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4283977 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL4285717 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL4283627 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL4285482 | — | IC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL2170108 | — | IC50 | = | 54000.0 | nM | 4.27 |
| CHEMBL4290522 | — | IC50 | = | 57000.0 | nM | 4.24 |
| CHEMBL4291901 | — | IC50 | = | 78000.0 | nM | 4.11 |
| CHEMBL4293926 | — | IC50 | = | 98000.0 | nM | 4.01 |
| CHEMBL4294027 | — | IC50 | - | — | - | |
| CHEMBL4278165 | — | IC50 | - | — | - | |
| CHEMBL1451226 | — | IC50 | - | — | - | |
| CHEMBL4283334 | — | IC50 | - | — | - | |
| CHEMBL4286684 | — | IC50 | - | — | - | |
| CHEMBL4278775 | — | IC50 | - | — | - | |
| CHEMBL4290114 | — | IC50 | - | — | - | |
| CHEMBL4282248 | — | IC50 | - | — | - | |
| CHEMBL4291839 | — | IC50 | - | — | - | |
| CHEMBL1543210 | — | IC50 | - | — | - | |
| CHEMBL4282057 | — | IC50 | - | — | - | |
| CHEMBL4289927 | — | IC50 | - | — | - | |
| CHEMBL4283944 | — | IC50 | - | — | - | |
| CHEMBL4280175 | — | IC50 | - | — | - | |
| CHEMBL1529748 | — | IC50 | - | — | - | |
| CHEMBL4295028 | — | IC50 | - | — | - | |
| CHEMBL4294214 | — | IC50 | - | — | - | |
| CHEMBL4284048 | — | IC50 | - | — | - | |
| CHEMBL4276745 | — | IC50 | - | — | - | |
| CHEMBL4285122 | — | IC50 | - | — | - | |
| CHEMBL4277171 | — | IC50 | - | — | - | |
| CHEMBL4292989 | — | IC50 | - | — | - | |
| CHEMBL259761 | — | IC50 | - | — | - | |
| CHEMBL4289111 | — | IC50 | - | — | - | |
| CHEMBL4278444 | — | IC50 | - | — | - | |
| CHEMBL4278849 | — | IC50 | - | — | - |