Assay Detail
Functional
CHEMBL4261102
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Antiparasitic activity against GFP-expressing Trypanosoma cruzi Tulahuen amastigote formss infected in cardiomyocytes assessed as reduction in rate of parasite multiplication within infected cardiomyocytes measured at 72 hrs post infection by fluorescence microscopy
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma cruzi |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Sterol 14α-Demethylase Structure-Based Optimization of Drug Candidates for Human Infections with the Protozoan Trypanosomatidae.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 9.00 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4276822 | — | — | 1 | 9.30 |
| CHEMBL3629567 | — | — | 1 | 9.00 |
| CHEMBL1236677 | — | — | 1 | 8.89 |
| CHEMBL4129161 | — | — | 1 | 8.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4276822 | — | EC50 | = | 0.5 | nM | 9.30 |
| CHEMBL3629567 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1236677 | — | EC50 | = | 1.3 | nM | 8.89 |
| CHEMBL4129161 | — | EC50 | = | 1.6 | nM | 8.80 |