Assay Detail
Binding
CHEMBL4261346
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human placental microsomal fraction 17beta-HSD2 using [3H]-E2 as substrate after 20 mins in presence of NAD+ by radio-flow detector based analysis
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
17-beta-hydroxysteroid dehydrogenase type 2 (CHEMBL2789) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Highly Potent 17β-HSD2 Inhibitors with a Promising Pharmacokinetic Profile for Targeted Osteoporosis Therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 8.48 | 9.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4293115 | — | — | 1 | 9.49 |
| CHEMBL4295076 | — | — | 1 | 9.20 |
| CHEMBL4276934 | — | — | 1 | 9.07 |
| CHEMBL4287575 | — | — | 1 | 8.96 |
| CHEMBL4284771 | — | — | 1 | 8.96 |
| CHEMBL4293119 | — | — | 1 | 8.96 |
| CHEMBL4286251 | — | — | 1 | 8.89 |
| CHEMBL4292910 | — | — | 1 | 8.89 |
| CHEMBL4092593 | — | — | 1 | 8.85 |
| CHEMBL4283851 | — | — | 1 | 8.80 |
| CHEMBL4283199 | — | — | 1 | 8.74 |
| CHEMBL4285743 | — | — | 1 | 8.70 |
| CHEMBL4276985 | — | — | 1 | 8.66 |
| CHEMBL4291052 | — | — | 1 | 8.64 |
| CHEMBL4290218 | — | — | 1 | 8.64 |
| CHEMBL4291714 | — | — | 1 | 8.59 |
| CHEMBL4286141 | — | — | 1 | 8.57 |
| CHEMBL4286097 | — | — | 1 | 8.51 |
| CHEMBL4277596 | — | — | 1 | 8.47 |
| CHEMBL4282320 | — | — | 1 | 8.42 |
| CHEMBL4279043 | — | — | 1 | 8.40 |
| CHEMBL4278956 | — | — | 1 | 8.36 |
| CHEMBL4282780 | — | — | 1 | 8.35 |
| CHEMBL4289526 | — | — | 1 | 8.28 |
| CHEMBL4280913 | — | — | 1 | 8.27 |
| CHEMBL4277362 | — | — | 1 | 8.27 |
| CHEMBL4288656 | — | — | 1 | 8.24 |
| CHEMBL4292504 | — | — | 1 | 8.22 |
| CHEMBL4278851 | — | — | 1 | 8.20 |
| CHEMBL4288245 | — | — | 1 | 8.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4293115 | — | IC50 | = | 0.32 | nM | 9.49 |
| CHEMBL4295076 | — | IC50 | = | 0.63 | nM | 9.20 |
| CHEMBL4276934 | — | IC50 | = | 0.85 | nM | 9.07 |
| CHEMBL4287575 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL4284771 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL4293119 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL4286251 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL4292910 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL4092593 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL4283851 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL4283199 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL4285743 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4276985 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL4291052 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL4290218 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL4291714 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL4286141 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL4286097 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL4277596 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL4282320 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL4279043 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4278956 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL4282780 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL4289526 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL4280913 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL4277362 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL4288656 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL4292504 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4278851 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL4288245 | — | IC50 | = | 7.1 | nM | 8.15 |
| CHEMBL4287316 | — | IC50 | = | 8.9 | nM | 8.05 |
| CHEMBL4294197 | — | IC50 | = | 9.2 | nM | 8.04 |
| CHEMBL4286742 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4289240 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4289569 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4104610 | — | IC50 | = | 299.0 | nM | 6.52 |