Compound Detail
CHEMBL4289569
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Basic Information
| ChEMBL ID | CHEMBL4289569 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HCUFSJFBLVAVGG-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
419.2
MW (Da)
5.78
ALogP
4
HBA
2
HBD
57.5
PSA (Ų)
0.42
QED
1
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 8.33
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 17-beta-hydroxysteroid dehydrogenase type 1 CHEMBL3181 | IC50 | 8.33 | 8.33 | 4.7 | 1 |
| 17-beta-hydroxysteroid dehydrogenase type 2 CHEMBL2789 | IC50 | 7.96 | 7.96 | 11.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 17-beta-hydroxysteroid dehydrogenase type 1 | IC50 | = | 4.7 | nM | 8.33 | Inhibition of human placental cytosolic 17beta-HSD1 using [3H]-E1 as substrate a... | 30480443 |
| 17-beta-hydroxysteroid dehydrogenase type 2 | IC50 | = | 11.0 | nM | 7.96 | Inhibition of human placental microsomal fraction 17beta-HSD2 using [3H]-E2 as s... | 30480443 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 30480443 | 10.1021/acs.jmedchem.8b01373 | 17-beta-hydroxysteroid dehydrogenase type 1 | 2 |
| 30480443 | 10.1021/acs.jmedchem.8b01373 | 17-beta-hydroxysteroid dehydrogenase type 2 | 1 |
| 30480443 | 10.1021/acs.jmedchem.8b01373 | Unchecked | 1 |
| 30480443 | 10.1021/acs.jmedchem.8b01373 | Estradiol 17-beta-dehydrogenase 2 | 1 |
Data from ChEMBL 36 via Core Engine