Assay Detail
Functional
CHEMBL4261464
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human DU145 cells after 72 hrs by MTT assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | DU-145 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Improving the Selectivity of PACE4 Inhibitors through Modifications of the P1 Residue.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 4.32 | 4.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4103458 | — | — | 1 | 4.60 |
| CHEMBL2179435 | — | — | 1 | 4.60 |
| CHEMBL4293336 | — | — | 1 | 4.40 |
| CHEMBL4289555 | — | — | 1 | 4.30 |
| CHEMBL4278214 | — | — | 1 | 4.21 |
| CHEMBL4285107 | — | — | 1 | 4.16 |
| CHEMBL2179834 | — | — | 1 | 4.16 |
| CHEMBL4277812 | — | — | 1 | 4.10 |
| CHEMBL4285511 | — | — | 1 | - |
| CHEMBL4292938 | — | — | 1 | - |
| CHEMBL4281675 | — | — | 1 | - |
| CHEMBL4286124 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4103458 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL2179435 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL4293336 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL4289555 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL4278214 | — | IC50 | = | 61000.0 | nM | 4.21 |
| CHEMBL4285107 | — | IC50 | = | 69000.0 | nM | 4.16 |
| CHEMBL2179834 | — | IC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL4277812 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL4285511 | — | IC50 | = | 110000.0 | nM | - |
| CHEMBL4292938 | — | IC50 | - | — | - | |
| CHEMBL4281675 | — | IC50 | - | — | - | |
| CHEMBL4286124 | — | IC50 | = | 130000.0 | nM | - |