Assay Detail
Binding
CHEMBL4263474
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Agonist activity at full length ERbeta (unknown origin) after 24 hrs by cell based ERE-driven luciferase reporter gene assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of 4-cycloheptylphenols as selective Estrogen receptor-β agonists (SERBAs).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 7.53 | 10.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL135 | ESTRADIOL | 4.0 | 1 | 10.66 |
| CHEMBL4293810 | — | — | 1 | 7.48 |
| CHEMBL4278672 | — | — | 1 | 7.32 |
| CHEMBL4283229 | — | — | 1 | 7.30 |
| CHEMBL4290786 | — | — | 1 | 7.29 |
| CHEMBL3099433 | — | — | 1 | 6.92 |
| CHEMBL4290019 | — | — | 1 | 6.86 |
| CHEMBL4279577 | — | — | 1 | 6.44 |
| CHEMBL4293632 | — | — | 1 | - |
| CHEMBL4283040 | — | — | 1 | - |
| CHEMBL4290239 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL135 | ESTRADIOL | EC50 | = | 0.022 | nM | 10.66 |
| CHEMBL4293810 | — | EC50 | = | 33.0 | nM | 7.48 |
| CHEMBL4278672 | — | EC50 | = | 48.0 | nM | 7.32 |
| CHEMBL4283229 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4290786 | — | EC50 | = | 51.0 | nM | 7.29 |
| CHEMBL3099433 | — | EC50 | = | 121.0 | nM | 6.92 |
| CHEMBL4290019 | — | EC50 | = | 139.0 | nM | 6.86 |
| CHEMBL4279577 | — | EC50 | = | 362.0 | nM | 6.44 |
| CHEMBL4293632 | — | EC50 | - | — | - | |
| CHEMBL4283040 | — | EC50 | - | — | - | |
| CHEMBL4290239 | — | EC50 | > | 800.0 | nM | - |