Assay Detail
Functional
CHEMBL4263554
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against Trypanosoma brucei rhodesiense STIB 900 trypomastigotes after 72 hrs by Alamar Blue assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei rhodesiense |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Trypanosoma brucei rhodesiense (CHEMBL612348) ↗| Type | ORGANISM |
| Organism | Trypanosoma brucei rhodesiense |
Publication
Natural products as inhibitors of Leishmania major dihydroorotate dehydrogenase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 4.54 | 5.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL145 | CAFFEIC ACID | 3.0 | 1 | 5.21 |
| CHEMBL226335 | RUTIN | 3.0 | 1 | 5.16 |
| CHEMBL150 | KAEMPFEROL | 1.0 | 1 | 4.49 |
| CHEMBL226034 | TAMARIXETIN | — | 1 | 4.33 |
| CHEMBL164 | MYRICETIN | — | 1 | 4.30 |
| CHEMBL311498 | CIANIDANOL | 4.0 | 1 | 4.30 |
| CHEMBL487017 | APIGETRIN | — | 1 | 4.28 |
| CHEMBL309490 | GALANGIN | — | 1 | 4.21 |
| CHEMBL51628 | UMBELLIFERONE | — | 1 | - |
| CHEMBL32749 | FERULATE | -1.0 | 1 | - |
| CHEMBL52564 | O-COUMARIC ACID | — | 1 | - |
| CHEMBL27246 | CINNAMIC ACID | — | 1 | - |
| CHEMBL37537 | PROTOCATECHUIC ACID | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL145 | CAFFEIC ACID | IC50 | = | 6110.0 | nM | 5.21 |
| CHEMBL226335 | RUTIN | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL150 | KAEMPFEROL | IC50 | = | 32160.0 | nM | 4.49 |
| CHEMBL226034 | TAMARIXETIN | IC50 | = | 46830.0 | nM | 4.33 |
| CHEMBL164 | MYRICETIN | IC50 | = | 49960.0 | nM | 4.30 |
| CHEMBL311498 | CIANIDANOL | IC50 | = | 49950.0 | nM | 4.30 |
| CHEMBL487017 | APIGETRIN | IC50 | = | 52500.0 | nM | 4.28 |
| CHEMBL309490 | GALANGIN | IC50 | = | 61060.0 | nM | 4.21 |
| CHEMBL51628 | UMBELLIFERONE | IC50 | = | 319480.0 | nM | - |
| CHEMBL32749 | FERULATE | IC50 | = | 427700.0 | nM | - |
| CHEMBL52564 | O-COUMARIC ACID | IC50 | = | 264980.0 | nM | - |
| CHEMBL27246 | CINNAMIC ACID | IC50 | = | 222900.0 | nM | - |
| CHEMBL37537 | PROTOCATECHUIC ACID | IC50 | = | 111600.0 | nM | - |