Assay Detail
Functional
CHEMBL4268248
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Antiproliferative activity against human Jurkat cells after 72 hrs by MTT assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Jurkat |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design and synthesis of potent dual inhibitors of JAK2 and HDAC based on fusing the pharmacophores of XL019 and vorinostat.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.84 | 6.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4095596 | — | — | 1 | 6.33 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.23 |
| CHEMBL4290748 | — | — | 1 | 5.99 |
| CHEMBL4294153 | — | — | 1 | 5.97 |
| CHEMBL4280540 | — | — | 1 | 5.92 |
| CHEMBL3917405 | — | — | 1 | 5.92 |
| CHEMBL4283921 | — | — | 1 | 5.75 |
| CHEMBL4291781 | — | — | 1 | 5.46 |
| CHEMBL4290689 | — | — | 1 | 5.00 |
| CHEMBL4284388 | — | — | 1 | - |
| CHEMBL4282456 | — | — | 1 | - |
| CHEMBL4278591 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4095596 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL4290748 | — | IC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL4294153 | — | IC50 | = | 1060.0 | nM | 5.97 |
| CHEMBL4280540 | — | IC50 | = | 1190.0 | nM | 5.92 |
| CHEMBL3917405 | — | IC50 | = | 1190.0 | nM | 5.92 |
| CHEMBL4283921 | — | IC50 | = | 1770.0 | nM | 5.75 |
| CHEMBL4291781 | — | IC50 | = | 3480.0 | nM | 5.46 |
| CHEMBL4290689 | — | IC50 | = | 9990.0 | nM | 5.00 |
| CHEMBL4284388 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4282456 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4278591 | — | IC50 | > | 10000.0 | nM | - |