Assay Detail
Binding
CHEMBL4268482
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of full length recombinant human N-terminal GST-tagged PDE11A4 expressed in baculovirus infected sf9 cells using FAM-cyclic-3',5-AMP as substrate after 1 hr by fluorescence polarization assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (CHEMBL2717) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of furyl/thienyl β-carboline derivatives as potent and selective PDE5 inhibitors with excellent vasorelaxant effect.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.83 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4292389 | — | — | 1 | 8.40 |
| CHEMBL779 | TADALAFIL | 4.0 | 1 | 7.33 |
| CHEMBL4289291 | — | — | 1 | 7.00 |
| CHEMBL4281590 | — | — | 1 | 6.92 |
| CHEMBL4287438 | — | — | 1 | 6.82 |
| CHEMBL4285199 | — | — | 1 | 6.81 |
| CHEMBL4281081 | — | — | 1 | 6.77 |
| CHEMBL4278136 | — | — | 1 | 6.76 |
| CHEMBL4289471 | — | — | 1 | 6.66 |
| CHEMBL4286052 | — | — | 1 | 6.57 |
| CHEMBL4291228 | — | — | 1 | 6.41 |
| CHEMBL4292970 | — | — | 1 | 6.20 |
| CHEMBL4284224 | — | — | 1 | 6.10 |
| CHEMBL4281766 | — | — | 1 | - |
| CHEMBL4277243 | — | — | 1 | - |
| CHEMBL4283473 | — | — | 1 | - |
| CHEMBL4280648 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4292389 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL779 | TADALAFIL | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL4289291 | — | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL4281590 | — | IC50 | = | 119.0 | nM | 6.92 |
| CHEMBL4287438 | — | IC50 | = | 153.0 | nM | 6.82 |
| CHEMBL4285199 | — | IC50 | = | 155.0 | nM | 6.81 |
| CHEMBL4281081 | — | IC50 | = | 169.0 | nM | 6.77 |
| CHEMBL4278136 | — | IC50 | = | 173.0 | nM | 6.76 |
| CHEMBL4289471 | — | IC50 | = | 219.0 | nM | 6.66 |
| CHEMBL4286052 | — | IC50 | = | 272.0 | nM | 6.57 |
| CHEMBL4291228 | — | IC50 | = | 386.0 | nM | 6.41 |
| CHEMBL4292970 | — | IC50 | = | 634.0 | nM | 6.20 |
| CHEMBL4284224 | — | IC50 | = | 802.0 | nM | 6.10 |
| CHEMBL4281766 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4277243 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4283473 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4280648 | — | IC50 | > | 1000.0 | nM | - |