Assay Detail
Binding
CHEMBL4270858
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Inhibition of ram seminal vesicle COX1 assessed as reduction in PGE2 formation pre-incubated for 5 mins before arachidonic acid addition and measured after 20 mins by ELISA
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Ovis aries |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Anti-inflammatory Activity of Natural Geranylated Flavonoids: Cyclooxygenase and Lipoxygenase Inhibitory Properties and Proteomic Analysis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.30 | 5.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL223256 | NYMPHAEOL A | — | 1 | 5.75 |
| CHEMBL463675 | — | — | 1 | 5.48 |
| CHEMBL374130 | BONANNIONE A | — | 1 | 5.43 |
| CHEMBL3581346 | — | — | 1 | 5.38 |
| CHEMBL521 | IBUPROFEN | 4.0 | 1 | 5.20 |
| CHEMBL4278258 | — | — | 1 | 4.58 |
| CHEMBL3581353 | — | — | 1 | - |
| CHEMBL463842 | — | — | 1 | - |
| CHEMBL4282134 | — | — | 1 | - |
| CHEMBL4293397 | — | — | 1 | - |
| CHEMBL93 | ZILEUTON | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL223256 | NYMPHAEOL A | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL463675 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL374130 | BONANNIONE A | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL3581346 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL521 | IBUPROFEN | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL4278258 | — | IC50 | = | 26300.0 | nM | 4.58 |
| CHEMBL3581353 | — | IC50 | - | — | - | |
| CHEMBL463842 | — | IC50 | - | — | - | |
| CHEMBL4282134 | — | IC50 | - | — | - | |
| CHEMBL4293397 | — | IC50 | - | — | - | |
| CHEMBL93 | ZILEUTON | IC50 | - | — | - |