Assay Detail
Functional
CHEMBL4275656
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Antiproliferative activity against human DU145 cells assessed as reduction in cell growth treated every 2 days for 4 days by hemocytometry
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | DU-145 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
5'-Chloro-2,2'-dihydroxychalcone and related flavanoids as treatments for prostate cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.31 | 5.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL75897 | 2'-HYDROXY-FLAVANONE | — | 1 | 5.39 |
| CHEMBL2297673 | — | — | 1 | 5.35 |
| CHEMBL4279841 | — | — | 1 | 5.30 |
| CHEMBL4283232 | — | — | 1 | 5.21 |
| CHEMBL4289590 | — | — | 1 | - |
| CHEMBL144278 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL75897 | 2'-HYDROXY-FLAVANONE | IC50 | = | 4110.0 | nM | 5.39 |
| CHEMBL2297673 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL4279841 | — | IC50 | = | 5030.0 | nM | 5.30 |
| CHEMBL4283232 | — | IC50 | = | 6130.0 | nM | 5.21 |
| CHEMBL4289590 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL144278 | — | IC50 | - | — | - |