Assay Detail
Functional
CHEMBL4275992
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Cytotoxicity against human DU145 cells assessed as reduction in cell viability after 48 hrs by MTT assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | DU-145 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Discovery of novel human inosine 5'-monophosphate dehydrogenase 2 (hIMPDH2) inhibitors as potential anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.73 | 6.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL359744 | DOXORUBICIN HYDROCHLORIDE | 4.0 | 1 | 6.68 |
| CHEMBL4279728 | — | — | 1 | 5.76 |
| CHEMBL4278234 | — | — | 1 | 5.72 |
| CHEMBL4287819 | — | — | 1 | 5.67 |
| CHEMBL4293371 | — | — | 1 | 5.59 |
| CHEMBL866 | MYCOPHENOLIC ACID | 4.0 | 1 | 5.53 |
| CHEMBL4292222 | — | — | 1 | 5.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL359744 | DOXORUBICIN HYDROCHLORIDE | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL4279728 | — | IC50 | = | 1750.0 | nM | 5.76 |
| CHEMBL4278234 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL4287819 | — | IC50 | = | 2130.0 | nM | 5.67 |
| CHEMBL4293371 | — | IC50 | = | 2550.0 | nM | 5.59 |
| CHEMBL866 | MYCOPHENOLIC ACID | IC50 | = | 2940.0 | nM | 5.53 |
| CHEMBL4292222 | — | IC50 | = | 6880.0 | nM | 5.16 |