Assay Detail
Binding
CHEMBL4276204
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Inhibition of [3H]serotonin uptake at SERT (unknown origin)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL228) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, synthesis, and systematic evaluation of 4-arylpiperazine- and 4-benzylpiperidine napthyl ethers as inhibitors of monoamine neurotransmitters reuptake.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.39 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3612833 | — | — | 1 | 7.00 |
| CHEMBL4073400 | — | — | 1 | 5.78 |
| CHEMBL288826 | — | — | 1 | - |
| CHEMBL4277585 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3612833 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4073400 | — | IC50 | = | 1670.0 | nM | 5.78 |
| CHEMBL288826 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4277585 | — | IC50 | > | 10000.0 | nM | - |