Assay Detail
Functional
CHEMBL4276244
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Antiproliferative activity against human SBC5 cells assessed as cell growth inhibition after 6 days by celltiter-glo luminescent cell viability assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SBC-5 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Discovery of Orally Active Inhibitors of Brahma Homolog (BRM)/SMARCA2 ATPase Activity for the Treatment of Brahma Related Gene 1 (BRG1)/SMARCA4-Mutant Cancers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 5.20 | 5.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4278436 | — | — | 1 | 5.20 |
| CHEMBL4295096 | — | — | 1 | - |
| CHEMBL4282980 | — | — | 1 | - |
| CHEMBL4293567 | — | — | 1 | - |
| CHEMBL4286345 | — | — | 1 | - |
| CHEMBL4294655 | — | — | 1 | - |
| CHEMBL4286757 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4278436 | — | EC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL4295096 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4282980 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4293567 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4286345 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4294655 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4286757 | — | EC50 | > | 10000.0 | nM | - |