Assay Detail
Binding
CHEMBL4276580
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-spiperone from dopamine D2 receptor in rat striatum homogenates after 30 mins by liquid scintillation counting
44
Total Activities
44
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Striatum |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and Biological Evaluation of Fused Tricyclic Heterocycle Piperazine (Piperidine) Derivatives As Potential Multireceptor Atypical Antipsychotics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 44 | 7.09 | 8.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4293999 | — | — | 1 | 8.54 |
| CHEMBL85 | RISPERIDONE | 4.0 | 1 | 8.43 |
| CHEMBL4290311 | — | — | 1 | 8.08 |
| CHEMBL4283548 | — | — | 1 | 8.00 |
| CHEMBL4289498 | — | — | 1 | 7.99 |
| CHEMBL4294799 | — | — | 1 | 7.87 |
| CHEMBL4276702 | — | — | 1 | 7.74 |
| CHEMBL4284435 | — | — | 1 | 7.74 |
| CHEMBL4281617 | — | — | 1 | 7.72 |
| CHEMBL4288409 | — | — | 1 | 7.71 |
| CHEMBL4286906 | — | — | 1 | 7.71 |
| CHEMBL4288766 | — | — | 1 | 7.55 |
| CHEMBL4284621 | — | — | 1 | 7.53 |
| CHEMBL4293659 | — | — | 1 | 7.50 |
| CHEMBL4291389 | — | — | 1 | 7.37 |
| CHEMBL4290255 | — | — | 1 | 7.36 |
| CHEMBL4279363 | — | — | 1 | 7.33 |
| CHEMBL4285041 | — | — | 1 | 7.30 |
| CHEMBL4287008 | — | — | 1 | 7.24 |
| CHEMBL4285781 | — | — | 1 | 7.21 |
| CHEMBL4283488 | — | — | 1 | 7.13 |
| CHEMBL4280873 | — | — | 1 | 7.07 |
| CHEMBL4277770 | — | — | 1 | 7.05 |
| CHEMBL4278627 | — | — | 1 | 7.05 |
| CHEMBL4288971 | — | — | 1 | 7.04 |
| CHEMBL4292889 | — | — | 1 | 6.98 |
| CHEMBL4288419 | — | — | 1 | 6.81 |
| CHEMBL4289001 | — | — | 1 | 6.74 |
| CHEMBL4281207 | — | — | 1 | 6.73 |
| CHEMBL4290422 | — | — | 1 | 6.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4293999 | — | Ki | = | 2.9 | nM | 8.54 |
| CHEMBL85 | RISPERIDONE | Ki | = | 3.7 | nM | 8.43 |
| CHEMBL4290311 | — | Ki | = | 8.4 | nM | 8.08 |
| CHEMBL4283548 | — | Ki | = | 9.9 | nM | 8.00 |
| CHEMBL4289498 | — | Ki | = | 10.3 | nM | 7.99 |
| CHEMBL4294799 | — | Ki | = | 13.4 | nM | 7.87 |
| CHEMBL4276702 | — | Ki | = | 18.3 | nM | 7.74 |
| CHEMBL4284435 | — | Ki | = | 18.2 | nM | 7.74 |
| CHEMBL4281617 | — | Ki | = | 19.2 | nM | 7.72 |
| CHEMBL4288409 | — | Ki | = | 19.7 | nM | 7.71 |
| CHEMBL4286906 | — | Ki | = | 19.6 | nM | 7.71 |
| CHEMBL4288766 | — | Ki | = | 28.4 | nM | 7.55 |
| CHEMBL4284621 | — | Ki | = | 29.7 | nM | 7.53 |
| CHEMBL4293659 | — | Ki | = | 31.8 | nM | 7.50 |
| CHEMBL4291389 | — | Ki | = | 43.2 | nM | 7.37 |
| CHEMBL4290255 | — | Ki | = | 44.2 | nM | 7.36 |
| CHEMBL4279363 | — | Ki | = | 46.5 | nM | 7.33 |
| CHEMBL4285041 | — | Ki | = | 49.9 | nM | 7.30 |
| CHEMBL4287008 | — | Ki | = | 58.2 | nM | 7.24 |
| CHEMBL4285781 | — | Ki | = | 62.1 | nM | 7.21 |
| CHEMBL4283488 | — | Ki | = | 74.3 | nM | 7.13 |
| CHEMBL4280873 | — | Ki | = | 85.8 | nM | 7.07 |
| CHEMBL4277770 | — | Ki | = | 88.8 | nM | 7.05 |
| CHEMBL4278627 | — | Ki | = | 89.1 | nM | 7.05 |
| CHEMBL4288971 | — | Ki | = | 91.4 | nM | 7.04 |
| CHEMBL4292889 | — | Ki | = | 104.3 | nM | 6.98 |
| CHEMBL4288419 | — | Ki | = | 154.2 | nM | 6.81 |
| CHEMBL4289001 | — | Ki | = | 182.1 | nM | 6.74 |
| CHEMBL4281207 | — | Ki | = | 187.6 | nM | 6.73 |
| CHEMBL4290422 | — | Ki | = | 185.2 | nM | 6.73 |
| CHEMBL4276681 | — | Ki | = | 188.8 | nM | 6.72 |
| CHEMBL4293347 | — | Ki | = | 282.5 | nM | 6.55 |
| CHEMBL4286835 | — | Ki | = | 394.3 | nM | 6.40 |
| CHEMBL4291828 | — | Ki | = | 574.3 | nM | 6.24 |
| CHEMBL4278918 | — | Ki | = | 582.1 | nM | 6.24 |
| CHEMBL4289351 | — | Ki | = | 861.2 | nM | 6.07 |
| CHEMBL4282378 | — | Ki | = | 900.3 | nM | 6.05 |
| CHEMBL4287810 | — | Ki | = | 1217.6 | nM | 5.91 |
| CHEMBL4284469 | — | Ki | = | 1660.8 | nM | 5.78 |
| CHEMBL4279959 | — | Ki | = | 1764.8 | nM | 5.75 |
| CHEMBL4286782 | — | Ki | = | 1852.9 | nM | 5.73 |
| CHEMBL4293833 | — | Ki | > | 2000.0 | nM | - |
| CHEMBL4295119 | — | Ki | > | 2000.0 | nM | - |
| CHEMBL4294685 | — | Ki | > | 2000.0 | nM | - |