Assay Detail
Binding
CHEMBL4303094
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-pentazocin from the Sigma1 receptor
7
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sigma non-opioid intracellular receptor 1 (CHEMBL287) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
A SARS-CoV-2 protein interaction map reveals targets for drug repurposing
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.31 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53325 | — | — | 1 | 8.70 |
| CHEMBL4088272 | — | — | 1 | 8.70 |
| CHEMBL1626 | CLEMASTINE | 4.0 | 1 | 8.00 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 7.10 |
| CHEMBL1535 | HYDROXYCHLOROQUINE | 4.0 | 1 | 6.90 |
| CHEMBL296419 | ASTEMIZOLE | 4.0 | 2 | 5.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53325 | — | Ki | = | 1.995 | nM | 8.70 |
| CHEMBL4088272 | — | Ki | = | 1.995 | nM | 8.70 |
| CHEMBL1626 | CLEMASTINE | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL76 | CHLOROQUINE | Ki | = | 79.43 | nM | 7.10 |
| CHEMBL1535 | HYDROXYCHLOROQUINE | Ki | = | 125.89 | nM | 6.90 |
| CHEMBL296419 | ASTEMIZOLE | Ki | = | 1266.0 | nM | 5.90 |
| CHEMBL296419 | ASTEMIZOLE | Ki | = | 1258.93 | nM | 5.90 |