Assay Detail
Functional
CHEMBL4305808
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human T47D cells assessed as reduction in cell growth incubated for 4 to 6 days by cell titer-glo luminescent cell viability assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | T47D |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of 6-(2-(dimethylamino)ethyl)-N-(5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole-6-yl)pyrimidin-2-yl)-5,6,7,8-tetrahydro-1,6-naphthyridin-2-amine as a highly potent cyclin-dependent kinase 4/6 inhibitor for treatment of cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 7.15 | 8.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4466497 | — | — | 1 | 8.14 |
| CHEMBL4550287 | — | — | 1 | 8.11 |
| CHEMBL4462493 | — | — | 1 | 8.08 |
| CHEMBL4448494 | — | — | 1 | 8.06 |
| CHEMBL4542247 | — | — | 1 | 8.00 |
| CHEMBL4445727 | — | — | 1 | 7.82 |
| CHEMBL4455210 | — | — | 1 | 7.71 |
| CHEMBL4449998 | — | — | 1 | 7.58 |
| CHEMBL4461442 | — | — | 1 | 7.54 |
| CHEMBL3301610 | ABEMACICLIB | 4.0 | 1 | 7.46 |
| CHEMBL4446626 | — | — | 1 | 7.32 |
| CHEMBL4438059 | — | — | 1 | 7.20 |
| CHEMBL4593340 | — | — | 1 | 7.20 |
| CHEMBL4453095 | — | — | 1 | 6.93 |
| CHEMBL4525034 | — | — | 1 | 6.85 |
| CHEMBL4458266 | — | — | 1 | 6.73 |
| CHEMBL4463172 | — | — | 1 | 6.47 |
| CHEMBL4438497 | — | — | 1 | 6.46 |
| CHEMBL4439999 | — | — | 1 | 6.12 |
| CHEMBL4463874 | — | — | 1 | 6.09 |
| CHEMBL4461579 | — | — | 1 | 5.77 |
| CHEMBL4463716 | — | — | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4466497 | — | IC50 | = | 7.21 | nM | 8.14 |
| CHEMBL4550287 | — | IC50 | = | 7.81 | nM | 8.11 |
| CHEMBL4462493 | — | IC50 | = | 8.26 | nM | 8.08 |
| CHEMBL4448494 | — | IC50 | = | 8.62 | nM | 8.06 |
| CHEMBL4542247 | — | IC50 | = | 10.1 | nM | 8.00 |
| CHEMBL4445727 | — | IC50 | = | 15.2 | nM | 7.82 |
| CHEMBL4455210 | — | IC50 | = | 19.4 | nM | 7.71 |
| CHEMBL4449998 | — | IC50 | = | 26.2 | nM | 7.58 |
| CHEMBL4461442 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL3301610 | ABEMACICLIB | IC50 | = | 34.3 | nM | 7.46 |
| CHEMBL4446626 | — | IC50 | = | 47.7 | nM | 7.32 |
| CHEMBL4438059 | — | IC50 | = | 62.8 | nM | 7.20 |
| CHEMBL4593340 | — | IC50 | = | 62.5 | nM | 7.20 |
| CHEMBL4453095 | — | IC50 | = | 118.0 | nM | 6.93 |
| CHEMBL4525034 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4458266 | — | IC50 | = | 188.0 | nM | 6.73 |
| CHEMBL4463172 | — | IC50 | = | 336.0 | nM | 6.47 |
| CHEMBL4438497 | — | IC50 | = | 344.0 | nM | 6.46 |
| CHEMBL4439999 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL4463874 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL4461579 | — | IC50 | = | 1681.0 | nM | 5.77 |
| CHEMBL4463716 | — | IC50 | = | 1999.0 | nM | 5.70 |