Assay Detail
Binding
CHEMBL4307074
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PRMT5 in human Granta-519 assessed as reduction in sDMA production incubated for 3 days by Western blotting analysis
7
Total Activities
6
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Granta-519 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Protein arginine N-methyltransferase 5 (CHEMBL1795116) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of Potent and Selective Covalent Protein Arginine Methyltransferase 5 (PRMT5) Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.44 | 7.92 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4518534 | — | — | 2 | 7.92 |
| CHEMBL4539373 | — | — | 1 | 7.66 |
| CHEMBL4548376 | — | — | 1 | 7.37 |
| CHEMBL4451469 | — | — | 1 | 6.80 |
| CHEMBL4475046 | — | — | 1 | - |
| CHEMBL4585395 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4518534 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4539373 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL4548376 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL4451469 | — | IC50 | = | 158.0 | nM | 6.80 |
| CHEMBL4475046 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4585395 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4518534 | — | Inhibition | - | % | - |