Assay Detail
Functional
CHEMBL4308248
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at Gi-coupled mu opioid receptor (unknown origin) expressed in HEK293T cells assessed as inhibition of cAMP production at pH 6.5 measured after 15 mins by Glo-Sensor assay
11
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
β-Fluorofentanyls Are pH-Sensitive Mu Opioid Receptor Agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 8.25 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4471584 | — | — | 2 | 9.15 |
| CHEMBL4468844 | — | — | 2 | 9.15 |
| CHEMBL38874 | DAMGO | — | 1 | 8.71 |
| CHEMBL596 | FENTANYL | 4.0 | 1 | 8.26 |
| CHEMBL4441320 | — | — | 1 | 8.26 |
| CHEMBL4458454 | — | — | 1 | 8.19 |
| CHEMBL4550454 | — | — | 1 | 7.93 |
| CHEMBL4516683 | — | — | 1 | 7.60 |
| CHEMBL4537210 | — | — | 1 | 5.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4471584 | — | IC50 | = | 0.7079 | nM | 9.15 |
| CHEMBL4468844 | — | IC50 | = | 0.7079 | nM | 9.15 |
| CHEMBL4468844 | — | IC50 | = | 0.71 | nM | 9.15 |
| CHEMBL4471584 | — | IC50 | = | 0.71 | nM | 9.15 |
| CHEMBL38874 | DAMGO | IC50 | = | 1.95 | nM | 8.71 |
| CHEMBL596 | FENTANYL | IC50 | = | 5.495 | nM | 8.26 |
| CHEMBL4441320 | — | IC50 | = | 5.495 | nM | 8.26 |
| CHEMBL4458454 | — | IC50 | = | 6.457 | nM | 8.19 |
| CHEMBL4550454 | — | IC50 | = | 11.75 | nM | 7.93 |
| CHEMBL4516683 | — | IC50 | = | 25.12 | nM | 7.60 |
| CHEMBL4537210 | — | IC50 | = | 5754.4 | nM | 5.24 |