Assay Detail
Functional
CHEMBL4308358
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against Trypanosoma cruzi Y strain amastigotes infected in human U2OS cells assessed as parasite growth inhibition after 72 hrs post infection by DRAQ5 staining based analysis
27
Total Activities
27
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma cruzi |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationship of nitrile-based cruzain inhibitors incorporating a trifluoroethylamine-based P2 amide replacement.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Activity | 23 | - | - |
| EC50 | 4 | 4.77 | 4.94 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4515535 | — | — | 1 | 4.94 |
| CHEMBL4535973 | — | — | 1 | 4.59 |
| CHEMBL4519995 | — | — | 1 | - |
| CHEMBL4546133 | — | — | 1 | - |
| CHEMBL4579894 | — | — | 1 | - |
| CHEMBL4543467 | — | — | 1 | - |
| CHEMBL4580196 | — | — | 1 | - |
| CHEMBL4544254 | — | — | 1 | - |
| CHEMBL4446278 | — | — | 1 | - |
| CHEMBL4514540 | — | — | 1 | - |
| CHEMBL4582238 | — | — | 1 | - |
| CHEMBL4439127 | — | — | 1 | - |
| CHEMBL4455305 | — | — | 1 | - |
| CHEMBL4471896 | — | — | 1 | - |
| CHEMBL4591985 | — | — | 1 | - |
| CHEMBL4565840 | — | — | 1 | - |
| CHEMBL4473385 | — | — | 1 | - |
| CHEMBL4452562 | — | — | 1 | - |
| CHEMBL4456233 | — | — | 1 | - |
| CHEMBL4586752 | — | — | 1 | - |
| CHEMBL4441186 | — | — | 1 | - |
| CHEMBL4440148 | — | — | 1 | - |
| CHEMBL481611 | ODANACATIB | 3.0 | 1 | - |
| CHEMBL4442543 | — | — | 1 | - |
| CHEMBL4463665 | — | — | 1 | - |
| CHEMBL4578891 | — | — | 1 | - |
| CHEMBL4451757 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4515535 | — | EC50 | = | 11500.0 | nM | 4.94 |
| CHEMBL4535973 | — | EC50 | = | 25600.0 | nM | 4.59 |
| CHEMBL4519995 | — | Activity | - | — | - | |
| CHEMBL4546133 | — | Activity | - | — | - | |
| CHEMBL4579894 | — | Activity | - | — | - | |
| CHEMBL4543467 | — | Activity | - | — | - | |
| CHEMBL4580196 | — | Activity | - | — | - | |
| CHEMBL4544254 | — | Activity | - | — | - | |
| CHEMBL4446278 | — | Activity | - | — | - | |
| CHEMBL4514540 | — | Activity | - | — | - | |
| CHEMBL4582238 | — | EC50 | - | — | - | |
| CHEMBL4439127 | — | Activity | - | — | - | |
| CHEMBL4455305 | — | Activity | - | — | - | |
| CHEMBL4471896 | — | Activity | - | — | - | |
| CHEMBL4591985 | — | Activity | - | — | - | |
| CHEMBL4565840 | — | Activity | - | — | - | |
| CHEMBL4473385 | — | Activity | - | — | - | |
| CHEMBL4452562 | — | Activity | - | — | - | |
| CHEMBL4456233 | — | Activity | - | — | - | |
| CHEMBL4586752 | — | Activity | - | — | - | |
| CHEMBL4441186 | — | Activity | - | — | - | |
| CHEMBL4440148 | — | Activity | - | — | - | |
| CHEMBL481611 | ODANACATIB | Activity | - | — | - | |
| CHEMBL4442543 | — | Activity | - | — | - | |
| CHEMBL4463665 | — | EC50 | - | — | - | |
| CHEMBL4578891 | — | Activity | - | — | - | |
| CHEMBL4451757 | — | Activity | - | — | - |