Assay Detail
Functional
CHEMBL4309309
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human IGROV1 cells harboring non targeted control shRNA sequence after 96 hrs by Cell-Titer Blue assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | IGROV-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Fluorine-Substituted Pyrrolo[2,3- d]Pyrimidine Analogues with Tumor Targeting via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide Biosynthesis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 8.22 | 8.94 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4538151 | — | — | 1 | 8.94 |
| CHEMBL4214638 | — | — | 1 | 8.81 |
| CHEMBL4465095 | — | — | 1 | 8.75 |
| CHEMBL192632 | — | — | 1 | 8.71 |
| CHEMBL4557278 | — | — | 1 | 8.29 |
| CHEMBL365307 | — | — | 1 | 8.28 |
| CHEMBL4445651 | — | — | 1 | 8.25 |
| CHEMBL4540298 | — | — | 1 | 8.16 |
| CHEMBL1834488 | — | — | 1 | 8.00 |
| CHEMBL3628344 | — | — | 1 | 7.89 |
| CHEMBL2158681 | — | — | 1 | 7.39 |
| CHEMBL225072 | PEMETREXED | 4.0 | 1 | 7.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4538151 | — | IC50 | = | 1.14 | nM | 8.94 |
| CHEMBL4214638 | — | IC50 | = | 1.55 | nM | 8.81 |
| CHEMBL4465095 | — | IC50 | = | 1.79 | nM | 8.75 |
| CHEMBL192632 | — | IC50 | = | 1.97 | nM | 8.71 |
| CHEMBL4557278 | — | IC50 | = | 5.17 | nM | 8.29 |
| CHEMBL365307 | — | IC50 | = | 5.21 | nM | 8.28 |
| CHEMBL4445651 | — | IC50 | = | 5.61 | nM | 8.25 |
| CHEMBL4540298 | — | IC50 | = | 6.89 | nM | 8.16 |
| CHEMBL1834488 | — | IC50 | = | 10.1 | nM | 8.00 |
| CHEMBL3628344 | — | IC50 | = | 12.8 | nM | 7.89 |
| CHEMBL2158681 | — | IC50 | = | 40.7 | nM | 7.39 |
| CHEMBL225072 | PEMETREXED | IC50 | = | 71.0 | nM | 7.15 |