Assay Detail
Functional
CHEMBL4311530
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Antiplatelet activity in ICR mouse platelet rich plasma assessed as inhibition of PAR4-AP-induced platelet aggregation pretreated for 5 mins followed by PAR4-AP addition by aggregometric analysis
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of BMS-986120 and its deuterated derivatives as PAR4 antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 8.08 | 8.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4483601 | — | — | 1 | 8.20 |
| CHEMBL4468894 | — | — | 1 | 8.16 |
| CHEMBL3716726 | — | — | 1 | 8.11 |
| CHEMBL4579732 | — | — | 1 | 8.11 |
| CHEMBL4540797 | — | — | 1 | 8.09 |
| CHEMBL4483498 | — | — | 1 | 8.06 |
| CHEMBL4548962 | — | — | 1 | 8.03 |
| CHEMBL4464044 | — | — | 1 | 7.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4483601 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL4468894 | — | IC50 | = | 6.97 | nM | 8.16 |
| CHEMBL3716726 | — | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL4579732 | — | IC50 | = | 7.69 | nM | 8.11 |
| CHEMBL4540797 | — | IC50 | = | 8.15 | nM | 8.09 |
| CHEMBL4483498 | — | IC50 | = | 8.74 | nM | 8.06 |
| CHEMBL4548962 | — | IC50 | = | 9.45 | nM | 8.03 |
| CHEMBL4464044 | — | IC50 | = | 14.5 | nM | 7.84 |