Assay Detail
Binding
CHEMBL4312088
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Antagonist activity at human recombinant beta2 adrenoreceptor expressed in CHOK1 cells incubated for 30 mins by HTRF
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Controlling cellular distribution of drugs with permeability modifying moieties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.28 | 8.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL266195 | ALPRENOLOL | 2.0 | 1 | 8.48 |
| CHEMBL4466532 | — | — | 1 | 8.16 |
| CHEMBL4458797 | — | — | 1 | 7.72 |
| CHEMBL4542960 | — | — | 1 | 7.66 |
| CHEMBL4459696 | — | — | 1 | 7.14 |
| CHEMBL4545079 | — | — | 1 | 7.08 |
| CHEMBL4475573 | — | — | 1 | 7.07 |
| CHEMBL4452249 | — | — | 1 | 7.02 |
| CHEMBL4587648 | — | — | 1 | 7.00 |
| CHEMBL4454523 | — | — | 1 | 6.42 |
| CHEMBL4527905 | — | — | 1 | 6.30 |
| CHEMBL4440189 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL266195 | ALPRENOLOL | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL4466532 | — | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL4458797 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4542960 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL4459696 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL4545079 | — | IC50 | = | 83.4 | nM | 7.08 |
| CHEMBL4475573 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL4452249 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL4587648 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4454523 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL4527905 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL4440189 | — | IC50 | > | 1000.0 | nM | - |