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Compound Detail

CHEMBL4454523

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CC(C)NCC(O)COc1ccccc1CCCSCC(=O)NCCOCCOCCNC(=O)C1C(C(=O)O)C(C(=O)O)C1C(=O)O

Basic Information

ChEMBL ID CHEMBL4454523
Phase Preclinical
Structure Type MOL
InChI Key GNTBQOIXPDGMJM-UHFFFAOYSA-N
2
Targets
3
Activities
2
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

685.8
MW (Da)
0.09
ALogP
11
HBA
7
HBD
230.1
PSA (Ų)
0.07
QED
3
Ro5 Violations
25
Rot. Bonds

Drug Information

Molecule Type Unknown
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C31H47N3O12S
MW 685.79
Aromatic Rings 1
Heavy Atoms 47
NP-Likeness -0.71

Activity Summary

Ki 2 meas. best 7.11
IC50 1 meas. best 6.42

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-2 adrenergic receptor
CHEMBL210
Ki 7.11 7.11 78.6 1
Beta-2 adrenergic receptor
CHEMBL210
IC50 6.42 6.42 380.0 1
5-hydroxytryptamine receptor 1A
CHEMBL214
Ki 5.76 5.76 1720.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
31303996 10.1039/C8MD00412A Beta-2 adrenergic receptor 4
31303996 10.1039/C8MD00412A 5-hydroxytryptamine receptor 1A 3

Data from ChEMBL 36 via Core Engine