Assay Detail
Functional
CHEMBL4313067
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Antiproliferative activity against human KG1 cells measured after 72 hrs by CCK8 assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KG-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery and Development of a Series of Pyrazolo[3,4-<i>d</i>]pyridazinone Compounds as the Novel Covalent Fibroblast Growth Factor Receptor Inhibitors by the Rational Drug Design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 8.06 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4448252 | — | — | 1 | 9.40 |
| CHEMBL4541330 | — | — | 1 | 9.22 |
| CHEMBL4447110 | — | — | 1 | 8.57 |
| CHEMBL3348846 | FEXAGRATINIB | 2.0 | 1 | 8.43 |
| CHEMBL4462946 | — | — | 1 | 8.43 |
| CHEMBL4586512 | — | — | 1 | 6.38 |
| CHEMBL4470504 | — | — | 1 | 5.96 |
| CHEMBL4446835 | — | — | 1 | - |
| CHEMBL4467025 | — | — | 1 | - |
| CHEMBL4463714 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4448252 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL4541330 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL4447110 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL3348846 | FEXAGRATINIB | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL4462946 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL4586512 | — | IC50 | = | 415.7 | nM | 6.38 |
| CHEMBL4470504 | — | IC50 | = | 1107.8 | nM | 5.96 |
| CHEMBL4446835 | — | IC50 | < | 0.3 | nM | - |
| CHEMBL4467025 | — | IC50 | < | 0.3 | nM | - |
| CHEMBL4463714 | — | IC50 | < | 0.3 | nM | - |