Compound Detail
CHEMBL4470504
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Basic Information
| ChEMBL ID | CHEMBL4470504 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FSSYFSGWGZLEBJ-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
357.4
MW (Da)
3.41
ALogP
6
HBA
2
HBD
102.7
PSA (Ų)
0.50
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.94
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fibroblast growth factor receptor 1 CHEMBL3650 | IC50 | 6.94 | 6.94 | 114.5 | 1 |
| KG-1 CHEMBL612264 | IC50 | 5.96 | 5.96 | 1107.8 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Fibroblast growth factor receptor 1 | IC50 | = | 114.5 | nM | 6.94 | Inhibition of human FGFR1 using poly (Glu, Tyr)4:1 as substrate measured after 6... | 31335138 |
| KG-1 | IC50 | = | 1107.8 | nM | 5.96 | Antiproliferative activity against human KG1 cells measured after 72 hrs by CCK8... | 31335138 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 31335138 | 10.1021/acs.jmedchem.9b00510 | Fibroblast growth factor receptor 1 | 1 |
| 31335138 | 10.1021/acs.jmedchem.9b00510 | KG-1 | 1 |
| 34821145 | 10.1021/acs.jmedchem.1c01205 | Epithelial discoidin domain-containing receptor 1 | 1 |
| 38452728 | 10.1016/j.ejmech.2024.116291 | Epithelial discoidin domain-containing receptor 1 | 1 |
Data from ChEMBL 36 via Core Engine