Assay Detail
Binding
CHEMBL4313650
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Inhibition of ovine COX-1 by EIA method
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Ovis aries |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
New oxadiazoles with selective-COX-2 and EGFR dual inhibitory activity: Design, synthesis, cytotoxicity evaluation and in silico studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 5.14 | 7.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | 7.39 |
| CHEMBL1034 | DICLOFENAC SODIUM | 4.0 | 1 | 5.42 |
| CHEMBL4529762 | — | — | 1 | 5.38 |
| CHEMBL3098650 | — | — | 1 | 5.35 |
| CHEMBL4465282 | — | — | 1 | 5.27 |
| CHEMBL4444316 | — | — | 1 | 5.24 |
| CHEMBL3098648 | — | — | 1 | 5.17 |
| CHEMBL4450458 | — | — | 1 | 5.17 |
| CHEMBL1322701 | — | — | 1 | 5.16 |
| CHEMBL4541315 | — | — | 1 | 5.12 |
| CHEMBL4576864 | — | — | 1 | 5.10 |
| CHEMBL4573875 | — | — | 1 | 5.08 |
| CHEMBL4450095 | — | — | 1 | 5.06 |
| CHEMBL4535881 | — | — | 1 | 5.03 |
| CHEMBL4475508 | — | — | 1 | 5.01 |
| CHEMBL4561572 | — | — | 1 | 5.01 |
| CHEMBL4569755 | — | — | 1 | 4.98 |
| CHEMBL4571604 | — | — | 1 | 4.97 |
| CHEMBL4462267 | — | — | 1 | 4.96 |
| CHEMBL4571917 | — | — | 1 | 4.95 |
| CHEMBL4449489 | — | — | 1 | 4.92 |
| CHEMBL4533452 | — | — | 1 | 4.90 |
| CHEMBL4582518 | — | — | 1 | 4.88 |
| CHEMBL4464158 | — | — | 1 | 4.86 |
| CHEMBL4440531 | — | — | 1 | 4.85 |
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 4.82 |
| CHEMBL4456191 | — | — | 1 | 4.81 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6 | INDOMETHACIN | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL1034 | DICLOFENAC SODIUM | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL4529762 | — | IC50 | = | 4170.0 | nM | 5.38 |
| CHEMBL3098650 | — | IC50 | = | 4490.0 | nM | 5.35 |
| CHEMBL4465282 | — | IC50 | = | 5390.0 | nM | 5.27 |
| CHEMBL4444316 | — | IC50 | = | 5710.0 | nM | 5.24 |
| CHEMBL3098648 | — | IC50 | = | 6780.0 | nM | 5.17 |
| CHEMBL4450458 | — | IC50 | = | 6840.0 | nM | 5.17 |
| CHEMBL1322701 | — | IC50 | = | 6870.0 | nM | 5.16 |
| CHEMBL4541315 | — | IC50 | = | 7540.0 | nM | 5.12 |
| CHEMBL4576864 | — | IC50 | = | 7960.0 | nM | 5.10 |
| CHEMBL4573875 | — | IC50 | = | 8290.0 | nM | 5.08 |
| CHEMBL4450095 | — | IC50 | = | 8690.0 | nM | 5.06 |
| CHEMBL4535881 | — | IC50 | = | 9370.0 | nM | 5.03 |
| CHEMBL4475508 | — | IC50 | = | 9810.0 | nM | 5.01 |
| CHEMBL4561572 | — | IC50 | = | 9870.0 | nM | 5.01 |
| CHEMBL4569755 | — | IC50 | = | 10540.0 | nM | 4.98 |
| CHEMBL4571604 | — | IC50 | = | 10590.0 | nM | 4.97 |
| CHEMBL4462267 | — | IC50 | = | 10870.0 | nM | 4.96 |
| CHEMBL4571917 | — | IC50 | = | 11360.0 | nM | 4.95 |
| CHEMBL4449489 | — | IC50 | = | 11980.0 | nM | 4.92 |
| CHEMBL4533452 | — | IC50 | = | 12690.0 | nM | 4.90 |
| CHEMBL4582518 | — | IC50 | = | 13080.0 | nM | 4.88 |
| CHEMBL4464158 | — | IC50 | = | 13740.0 | nM | 4.86 |
| CHEMBL4440531 | — | IC50 | = | 14210.0 | nM | 4.85 |
| CHEMBL118 | CELECOXIB | IC50 | = | 15100.0 | nM | 4.82 |
| CHEMBL4456191 | — | IC50 | = | 15380.0 | nM | 4.81 |