Assay Detail
Binding
CHEMBL4314363
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-imipramine from human serotonin transporter expressed in HEK293 cells membranes incubated for 30 mins by microbeta scintillation counting analysis
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL228) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and biological evaluation of new multi-target 3-(1H-indol-3-yl)pyrrolidine-2,5-dione derivatives with potential antidepressant effect.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 25 | 7.03 | 8.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL439849 | VILAZODONE | 4.0 | 1 | 8.72 |
| CHEMBL11 | IMIPRAMINE | 4.0 | 1 | 8.60 |
| CHEMBL4571321 | — | — | 1 | 7.76 |
| CHEMBL4553259 | — | — | 1 | 7.52 |
| CHEMBL4515160 | — | — | 1 | 7.49 |
| CHEMBL4571862 | — | — | 1 | 7.29 |
| CHEMBL4456442 | — | — | 1 | 7.20 |
| CHEMBL4591262 | — | — | 1 | 6.99 |
| CHEMBL4451635 | — | — | 1 | 6.96 |
| CHEMBL4567029 | — | — | 1 | 6.85 |
| CHEMBL4470395 | — | — | 1 | 6.85 |
| CHEMBL4470604 | — | — | 1 | 6.82 |
| CHEMBL4587314 | — | — | 1 | 6.81 |
| CHEMBL4454176 | — | — | 1 | 6.70 |
| CHEMBL4461198 | — | — | 1 | 6.66 |
| CHEMBL4591440 | — | — | 1 | 6.51 |
| CHEMBL4472066 | — | — | 1 | 6.50 |
| CHEMBL4482920 | — | — | 1 | 6.28 |
| CHEMBL4483554 | — | — | 1 | 6.15 |
| CHEMBL4572132 | — | — | 1 | 5.88 |
| CHEMBL39 | SEROTONIN | 3.0 | 1 | - |
| CHEMBL4474439 | — | — | 1 | - |
| CHEMBL4461080 | — | — | 1 | - |
| CHEMBL4567158 | — | — | 1 | - |
| CHEMBL4437024 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL439849 | VILAZODONE | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL11 | IMIPRAMINE | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL4571321 | — | Ki | = | 17.5 | nM | 7.76 |
| CHEMBL4553259 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL4515160 | — | Ki | = | 32.4 | nM | 7.49 |
| CHEMBL4571862 | — | Ki | = | 51.0 | nM | 7.29 |
| CHEMBL4456442 | — | Ki | = | 63.0 | nM | 7.20 |
| CHEMBL4591262 | — | Ki | = | 102.0 | nM | 6.99 |
| CHEMBL4451635 | — | Ki | = | 111.0 | nM | 6.96 |
| CHEMBL4567029 | — | Ki | = | 141.8 | nM | 6.85 |
| CHEMBL4470395 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL4470604 | — | Ki | = | 150.5 | nM | 6.82 |
| CHEMBL4587314 | — | Ki | = | 156.0 | nM | 6.81 |
| CHEMBL4454176 | — | Ki | = | 201.0 | nM | 6.70 |
| CHEMBL4461198 | — | Ki | = | 221.0 | nM | 6.66 |
| CHEMBL4591440 | — | Ki | = | 308.0 | nM | 6.51 |
| CHEMBL4472066 | — | Ki | = | 314.0 | nM | 6.50 |
| CHEMBL4482920 | — | Ki | = | 523.0 | nM | 6.28 |
| CHEMBL4483554 | — | Ki | = | 705.0 | nM | 6.15 |
| CHEMBL4572132 | — | Ki | = | 1313.0 | nM | 5.88 |
| CHEMBL39 | SEROTONIN | Ki | - | — | - | |
| CHEMBL4474439 | — | Ki | - | — | - | |
| CHEMBL4461080 | — | Ki | - | — | - | |
| CHEMBL4567158 | — | Ki | - | — | - | |
| CHEMBL4437024 | — | Ki | - | — | - |