Assay Detail
Binding
CHEMBL4322118
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of rat synaptosome SERT
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL313) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Rational Design of Multitarget-Directed Ligands: Strategies and Emerging Paradigms.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.45 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL197696 | — | — | 1 | 8.22 |
| CHEMBL194372 | — | — | 1 | 7.38 |
| CHEMBL41 | FLUOXETINE | 4.0 | 1 | 6.75 |
| CHEMBL636 | RIVASTIGMINE | 4.0 | 1 | - |
| CHEMBL497071 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL197696 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL194372 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL41 | FLUOXETINE | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL636 | RIVASTIGMINE | IC50 | > | 1000.0 | nM | - |
| CHEMBL497071 | — | IC50 | > | 1000.0 | nM | - |