Assay Detail
Binding
CHEMBL4324463
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Binding affinity to MT2 receptor (unknown origin) assessed as inhibition constant
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Indole-based melatonin analogues: Synthetic approaches and biological activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 9.23 | 9.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL45 | MELATONIN | 4.0 | 1 | 9.74 |
| CHEMBL34730 | — | — | 1 | 9.70 |
| CHEMBL127421 | — | — | 1 | 8.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL45 | MELATONIN | Ki | = | 0.18 | nM | 9.74 |
| CHEMBL34730 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL127421 | — | Ki | = | 5.5 | nM | 8.26 |