Assay Detail
ADMET
CHEMBL4329574
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Cytotoxicity against rat bone marrow cells assessed as reduction in cell viability after 72 hrs by celltiter glo assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Rattus norvegicus |
| Cell Type | Bone marrow cell |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of N-(piperidin-3-yl)-N-(pyridin-2-yl)piperidine/piperazine-1-carboxamides as small molecule inhibitors of PCSK9.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.82 | 5.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4574496 | — | — | 1 | 5.50 |
| CHEMBL4554909 | — | — | 1 | 5.00 |
| CHEMBL4560206 | — | — | 1 | 4.93 |
| CHEMBL4534859 | — | — | 1 | 4.90 |
| CHEMBL4533299 | — | — | 1 | 4.57 |
| CHEMBL4525277 | — | — | 1 | 4.51 |
| CHEMBL4527910 | — | — | 1 | 4.33 |
| CHEMBL4469712 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4574496 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL4554909 | — | IC50 | = | 10100.0 | nM | 5.00 |
| CHEMBL4560206 | — | IC50 | = | 11700.0 | nM | 4.93 |
| CHEMBL4534859 | — | IC50 | = | 12700.0 | nM | 4.90 |
| CHEMBL4533299 | — | IC50 | = | 27100.0 | nM | 4.57 |
| CHEMBL4525277 | — | IC50 | = | 31100.0 | nM | 4.51 |
| CHEMBL4527910 | — | IC50 | = | 46200.0 | nM | 4.33 |
| CHEMBL4469712 | — | IC50 | > | 100000.0 | nM | - |