Compound Detail
CHEMBL4525277
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Cc1ccc2c(N3CCN(C(=O)N(c4nccc5ccccc45)[C@@H]4CCCNC4)CC3)noc2c1
Basic Information
| ChEMBL ID | CHEMBL4525277 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | XBYACMMWHFGWFW-OAQYLSRUSA-N |
3
Targets
3
Activities
2
Assay Types
1
PK Parameters
5
Publications
0
Known Names
Molecular Properties
470.6
MW (Da)
4.19
ALogP
6
HBA
1
HBD
77.7
PSA (Ų)
0.48
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.46
Ki 1 meas. best 5.92
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Voltage-gated inwardly rectifying potassium channel KCNH2 CHEMBL240 | Ki | 5.92 | 5.92 | 1200.0 | 1 |
| 80S Ribosome CHEMBL3987582 | IC50 | 5.46 | 5.46 | 3500.0 | 1 |
| Bone marrow cell CHEMBL4296515 | IC50 | 4.51 | 4.51 | 31100.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 12.9 | mL.min-1.g-1 | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Voltage-gated inwardly rectifying potassium channel KCNH2 | Ki | = | 1200.0 | nM | 5.92 | Binding affinity to human ERG by dofetilide fluorescence polarization binding as... | 30482620 |
| 80S Ribosome | IC50 | = | 3500.0 | nM | 5.46 | Binding affinity to 80S ribosome in human HuH7 cells harboring human PCSK9 (1 to... | 30482620 |
| Bone marrow cell | IC50 | = | 31100.0 | nM | 4.51 | Cytotoxicity against rat bone marrow cells assessed as reduction in cell viabili... | 30482620 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 30482620 | 10.1016/j.bmcl.2018.10.029 | ADMET | 2 |
| 30482620 | 10.1016/j.bmcl.2018.10.029 | 80S Ribosome | 1 |
| 30482620 | 10.1016/j.bmcl.2018.10.029 | No relevant target | 1 |
| 30482620 | 10.1016/j.bmcl.2018.10.029 | Bone marrow cell | 1 |
| 30482620 | 10.1016/j.bmcl.2018.10.029 | Voltage-gated inwardly rectifying potassium channel KCNH2 | 1 |
Data from ChEMBL 36 via Core Engine