Assay Detail
Functional
CHEMBL4330239
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against p53 gene knocked out human HCT116 cells after 3 days by MTS assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and Cytotoxic and Antiviral Profiling of Pyrrolo- and Furo-Fused 7-Deazapurine Ribonucleosides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 5.87 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1814768 | — | — | 1 | 7.70 |
| CHEMBL4532596 | — | — | 1 | 6.82 |
| CHEMBL4591383 | — | — | 1 | 6.68 |
| CHEMBL4483740 | — | — | 1 | 6.52 |
| CHEMBL4467186 | — | — | 1 | 6.48 |
| CHEMBL4567695 | — | — | 1 | 6.42 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 6.39 |
| CHEMBL4585910 | — | — | 1 | 6.35 |
| CHEMBL4450152 | — | — | 1 | 6.21 |
| CHEMBL4576288 | — | — | 1 | 5.40 |
| CHEMBL4585392 | — | — | 1 | 5.05 |
| CHEMBL4589727 | — | — | 1 | 4.97 |
| CHEMBL4554008 | — | — | 1 | 4.44 |
| CHEMBL4438098 | — | — | 1 | 4.33 |
| CHEMBL4470770 | — | — | 1 | 4.32 |
| CHEMBL4580524 | — | — | 1 | - |
| CHEMBL4589668 | — | — | 1 | - |
| CHEMBL4556165 | — | — | 1 | - |
| CHEMBL4447775 | — | — | 1 | - |
| CHEMBL4458110 | — | — | 1 | - |
| CHEMBL4556038 | — | — | 1 | - |
| CHEMBL4455893 | — | — | 1 | - |
| CHEMBL4543054 | — | — | 1 | - |
| CHEMBL4476539 | — | — | 1 | - |
| CHEMBL4462344 | — | — | 1 | - |
| CHEMBL4517245 | — | — | 1 | - |
| CHEMBL4462448 | — | — | 1 | - |
| CHEMBL4454930 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1814768 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4532596 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL4591383 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL4483740 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4467186 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL4567695 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL4585910 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL4450152 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL4576288 | — | IC50 | = | 4010.0 | nM | 5.40 |
| CHEMBL4585392 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL4589727 | — | IC50 | = | 10720.0 | nM | 4.97 |
| CHEMBL4554008 | — | IC50 | = | 36370.0 | nM | 4.44 |
| CHEMBL4438098 | — | IC50 | = | 46450.0 | nM | 4.33 |
| CHEMBL4470770 | — | IC50 | = | 47530.0 | nM | 4.32 |
| CHEMBL4580524 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4589668 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4556165 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4447775 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4458110 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4556038 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4455893 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4543054 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4476539 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4462344 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4517245 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4462448 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4454930 | — | IC50 | > | 50000.0 | nM | - |