Assay Detail
Functional
CHEMBL4330507
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Antiproliferative activity against human A2780 cells after 72 hrs by SRB assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A2780 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
New naphthopyran analogues of LY290181 as potential tumor vascular-disrupting agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 6.87 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4473535 | — | — | 1 | 7.92 |
| CHEMBL4475290 | — | — | 1 | 7.83 |
| CHEMBL4469871 | — | — | 1 | 7.79 |
| CHEMBL4471330 | — | — | 1 | 7.78 |
| CHEMBL4464137 | — | — | 1 | 7.77 |
| CHEMBL321336 | — | — | 1 | 7.73 |
| CHEMBL4442805 | — | — | 1 | 7.31 |
| CHEMBL4436712 | — | — | 1 | 7.30 |
| CHEMBL4586497 | — | — | 1 | 7.21 |
| CHEMBL4547354 | — | — | 1 | 6.98 |
| CHEMBL4586349 | — | — | 1 | 6.81 |
| CHEMBL4435920 | — | — | 1 | 6.80 |
| CHEMBL4436683 | — | — | 1 | 6.73 |
| CHEMBL4441682 | — | — | 1 | 6.44 |
| CHEMBL4567907 | — | — | 1 | 6.12 |
| CHEMBL4451738 | — | — | 1 | 6.04 |
| CHEMBL4459676 | — | — | 1 | 5.97 |
| CHEMBL4558563 | — | — | 1 | 5.84 |
| CHEMBL4585739 | — | — | 1 | 5.67 |
| CHEMBL4536562 | — | — | 1 | 5.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4473535 | — | IC50 | = | 12.1 | nM | 7.92 |
| CHEMBL4475290 | — | IC50 | = | 14.8 | nM | 7.83 |
| CHEMBL4469871 | — | IC50 | = | 16.4 | nM | 7.79 |
| CHEMBL4471330 | — | IC50 | = | 16.7 | nM | 7.78 |
| CHEMBL4464137 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL321336 | — | IC50 | = | 18.7 | nM | 7.73 |
| CHEMBL4442805 | — | IC50 | = | 48.5 | nM | 7.31 |
| CHEMBL4436712 | — | IC50 | = | 49.9 | nM | 7.30 |
| CHEMBL4586497 | — | IC50 | = | 61.1 | nM | 7.21 |
| CHEMBL4547354 | — | IC50 | = | 104.0 | nM | 6.98 |
| CHEMBL4586349 | — | IC50 | = | 155.0 | nM | 6.81 |
| CHEMBL4435920 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4436683 | — | IC50 | = | 188.0 | nM | 6.73 |
| CHEMBL4441682 | — | IC50 | = | 363.0 | nM | 6.44 |
| CHEMBL4567907 | — | IC50 | = | 759.0 | nM | 6.12 |
| CHEMBL4451738 | — | IC50 | = | 912.0 | nM | 6.04 |
| CHEMBL4459676 | — | IC50 | = | 1066.0 | nM | 5.97 |
| CHEMBL4558563 | — | IC50 | = | 1439.0 | nM | 5.84 |
| CHEMBL4585739 | — | IC50 | = | 2150.0 | nM | 5.67 |
| CHEMBL4536562 | — | IC50 | = | 5164.0 | nM | 5.29 |