Assay Detail
ADMET
CHEMBL4331639
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Inhibition of CYP3A4 in human liver microsomes by LC-MS/MS analysis
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Tissue | Liver |
| Subcellular | Microsomes |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development of posaconazole-based analogues as hedgehog signaling pathway inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.11 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL64391 | ITRACONAZOLE | 4.0 | 1 | 7.40 |
| CHEMBL1397 | POSACONAZOLE | 4.0 | 1 | 6.82 |
| CHEMBL4450683 | — | — | 1 | - |
| CHEMBL4461707 | — | — | 1 | - |
| CHEMBL4587117 | — | — | 1 | - |
| CHEMBL4540110 | — | — | 1 | - |
| CHEMBL4460235 | — | — | 1 | - |
| CHEMBL4458878 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL64391 | ITRACONAZOLE | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1397 | POSACONAZOLE | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL4450683 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4461707 | — | IC50 | - | — | - | |
| CHEMBL4587117 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4540110 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4460235 | — | IC50 | - | — | - | |
| CHEMBL4458878 | — | IC50 | - | — | - |