Assay Detail
Functional
CHEMBL4333170
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Agonist activity at mu-opioid receptor (unknown origin) expressed in HEK293A cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins
9
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of two novel branched peptidomimetics containing endomorphin-2 and RF9 pharmacophores: Synthesis and neuropharmacological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 6.25 | 7.30 |
| Emax | 3 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL333357 | ENDOMORPHIN 2 | — | 3 | 7.30 |
| CHEMBL4449491 | — | — | 3 | 5.80 |
| CHEMBL4442534 | — | — | 3 | 5.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL333357 | ENDOMORPHIN 2 | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL333357 | ENDOMORPHIN 2 | EC50 | = | 63.1 | nM | 7.20 |
| CHEMBL4449491 | — | EC50 | = | 1584.89 | nM | 5.80 |
| CHEMBL4449491 | — | EC50 | = | 1770.0 | nM | 5.75 |
| CHEMBL4442534 | — | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL4442534 | — | EC50 | = | 1995.26 | nM | 5.70 |
| CHEMBL4449491 | — | Emax | = | 54.3 | % | - |
| CHEMBL333357 | ENDOMORPHIN 2 | Emax | = | 76.8 | % | - |
| CHEMBL4442534 | — | Emax | = | 62.0 | % | - |