Assay Detail

CHEMBL4333882

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Functional

Cytotoxicity against human NB4 cells after 48 hrs by MTT assay

ChEMBL ↗

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Target

NB-4 (CHEMBL614188) ↗

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NB-4 (CHEMBL614188) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target NB-4

CHEMBL614188

Anchored from Assay target.

Protein identity NB-4

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	NB-4
Confidence	1 — Organism
Curated By	Autocuration

Target

NB-4 (CHEMBL614188) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

A mitochondria-targeted organic arsenical accelerates mitochondrial metabolic disorder and function injury.

Fan XY, Liu YJ, Cai YM, Wang AD, Xia YZ, Hu YJ, Jiang FL, Liu Y.
Bioorg Med Chem (2019) 27 : 760 -768
PubMed 30665675 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	6.19	6.29

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL4450700	—	—	1	6.29
CHEMBL3290761	—	—	1	6.09

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL4450700	—	IC50	=	510.0	nM	6.29
CHEMBL3290761	—	IC50	=	820.0	nM	6.09