Assay Detail

CHEMBL4334780

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Functional

Antiproliferative activity against human A2780 cells incubated for 4 days by MTT assay

ChEMBL ↗

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Target

A2780 (CHEMBL614004) ↗

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Primary target A2780

CHEMBL614004

Anchored from Assay target.

Protein identity A2780

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	A2780
Confidence	1 — Organism
Curated By	Autocuration

Target

A2780 (CHEMBL614004) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

A cell-based screening system for RNA polymerase I inhibitors.

Tan X, Awuah SG.
Medchemcomm (2019) 10 : 1765 -1774
PubMed 31803394 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	6.54	6.92

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL4303309	CX-5461	1.0	1	6.92
CHEMBL1200563	CERIVASTATIN SODIUM	4.0	1	6.16

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL4303309	CX-5461	IC50	=	120.0	nM	6.92
CHEMBL1200563	CERIVASTATIN SODIUM	IC50	=	700.0	nM	6.16