Assay Detail
Binding
CHEMBL4338396
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activation of recombinant human wild-type STING expressed in 293T cells incubated for 7 hrs in absence of digitonin A by bright Glo-luciferase reporter gene assay
42
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Stimulator of interferon genes protein (CHEMBL4523377) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Enzymatic Preparation of 2'-5',3'-5'-Cyclic Dinucleotides, Their Binding Properties to Stimulator of Interferon Genes Adaptor Protein, and Structure/Activity Correlations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 42 | 4.62 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4438957 | — | — | 4 | 6.00 |
| CHEMBL4476079 | — | — | 1 | 4.97 |
| CHEMBL4446841 | — | — | 1 | 4.96 |
| CHEMBL4468010 | — | — | 1 | 4.88 |
| CHEMBL4466863 | — | — | 1 | 4.88 |
| CHEMBL4465054 | — | — | 1 | 4.86 |
| CHEMBL4577528 | — | — | 1 | 4.86 |
| CHEMBL1229884 | — | — | 1 | 4.83 |
| CHEMBL4459563 | — | — | 1 | 4.82 |
| CHEMBL4589856 | — | — | 1 | 4.78 |
| CHEMBL4570468 | — | — | 1 | 4.67 |
| CHEMBL4544112 | — | — | 1 | 4.56 |
| CHEMBL4552089 | — | — | 1 | 4.52 |
| CHEMBL4474321 | — | — | 1 | 4.50 |
| CHEMBL4540223 | — | — | 1 | 4.45 |
| CHEMBL4435159 | — | — | 1 | 4.41 |
| CHEMBL4573074 | — | — | 1 | 4.40 |
| CHEMBL4539147 | — | — | 1 | 4.39 |
| CHEMBL4462144 | — | — | 1 | 4.27 |
| CHEMBL4439796 | — | — | 1 | 4.24 |
| CHEMBL4526526 | — | — | 1 | 4.20 |
| CHEMBL4578839 | — | — | 1 | 4.18 |
| CHEMBL4449584 | — | — | 1 | 4.15 |
| CHEMBL4566174 | — | — | 1 | 4.12 |
| CHEMBL4573882 | — | — | 1 | - |
| CHEMBL4556336 | — | — | 1 | - |
| CHEMBL4591097 | — | — | 1 | - |
| CHEMBL1231573 | — | — | 1 | - |
| CHEMBL4588248 | — | — | 1 | - |
| CHEMBL4566128 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4438957 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4438957 | — | EC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL4476079 | — | EC50 | = | 10700.0 | nM | 4.97 |
| CHEMBL4446841 | — | EC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL4468010 | — | EC50 | = | 13300.0 | nM | 4.88 |
| CHEMBL4466863 | — | EC50 | = | 13300.0 | nM | 4.88 |
| CHEMBL4577528 | — | EC50 | = | 13800.0 | nM | 4.86 |
| CHEMBL4465054 | — | EC50 | = | 13700.0 | nM | 4.86 |
| CHEMBL1229884 | — | EC50 | = | 14900.0 | nM | 4.83 |
| CHEMBL4459563 | — | EC50 | = | 15100.0 | nM | 4.82 |
| CHEMBL4589856 | — | EC50 | = | 16700.0 | nM | 4.78 |
| CHEMBL4570468 | — | EC50 | = | 21600.0 | nM | 4.67 |
| CHEMBL4544112 | — | EC50 | = | 27600.0 | nM | 4.56 |
| CHEMBL4552089 | — | EC50 | = | 29900.0 | nM | 4.52 |
| CHEMBL4474321 | — | EC50 | = | 31900.0 | nM | 4.50 |
| CHEMBL4540223 | — | EC50 | = | 35900.0 | nM | 4.45 |
| CHEMBL4435159 | — | EC50 | = | 39200.0 | nM | 4.41 |
| CHEMBL4573074 | — | EC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL4539147 | — | EC50 | = | 40400.0 | nM | 4.39 |
| CHEMBL4462144 | — | EC50 | = | 53900.0 | nM | 4.27 |
| CHEMBL4439796 | — | EC50 | = | 58200.0 | nM | 4.24 |
| CHEMBL4526526 | — | EC50 | = | 63700.0 | nM | 4.20 |
| CHEMBL4578839 | — | EC50 | = | 66400.0 | nM | 4.18 |
| CHEMBL4438957 | — | EC50 | = | 70700.0 | nM | 4.15 |
| CHEMBL4449584 | — | EC50 | = | 70100.0 | nM | 4.15 |
| CHEMBL4566174 | — | EC50 | = | 75400.0 | nM | 4.12 |
| CHEMBL4445083 | — | EC50 | > | 300000.0 | nM | - |
| CHEMBL4465931 | — | EC50 | = | 107500.0 | nM | - |
| CHEMBL4441395 | — | EC50 | - | — | - | |
| CHEMBL4444544 | — | EC50 | = | 186800.0 | nM | - |
| CHEMBL4517384 | — | EC50 | = | 148800.0 | nM | - |
| CHEMBL4553050 | — | EC50 | > | 300000.0 | nM | - |
| CHEMBL4586305 | — | EC50 | = | 182100.0 | nM | - |
| CHEMBL4465353 | — | EC50 | > | 300000.0 | nM | - |
| CHEMBL4566810 | — | EC50 | > | 300000.0 | nM | - |
| CHEMBL4566128 | — | EC50 | > | 300000.0 | nM | - |
| CHEMBL4588248 | — | EC50 | > | 300000.0 | nM | - |
| CHEMBL4591097 | — | EC50 | = | 240600.0 | nM | - |
| CHEMBL4556336 | — | EC50 | > | 300000.0 | nM | - |
| CHEMBL4573882 | — | EC50 | - | — | - | |
| CHEMBL4438957 | — | EC50 | = | 120600.0 | nM | - |
| CHEMBL1231573 | — | EC50 | = | 184200.0 | nM | - |