Assay Detail
Binding
CHEMBL4338397
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activation of recombinant human wild-type STING expressed in 293T cells measured after 30 mins in presence of digitonin A by bright Glo-luciferase reporter gene assay
42
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Stimulator of interferon genes protein (CHEMBL4523377) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Enzymatic Preparation of 2'-5',3'-5'-Cyclic Dinucleotides, Their Binding Properties to Stimulator of Interferon Genes Adaptor Protein, and Structure/Activity Correlations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 42 | 7.28 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4578839 | — | — | 1 | 8.00 |
| CHEMBL4466863 | — | — | 1 | 8.00 |
| CHEMBL4577528 | — | — | 1 | 8.00 |
| CHEMBL4570468 | — | — | 1 | 8.00 |
| CHEMBL4459563 | — | — | 1 | 8.00 |
| CHEMBL4465931 | — | — | 1 | 7.70 |
| CHEMBL4476079 | — | — | 1 | 7.70 |
| CHEMBL4446841 | — | — | 1 | 7.70 |
| CHEMBL4544112 | — | — | 1 | 7.70 |
| CHEMBL4589856 | — | — | 1 | 7.70 |
| CHEMBL4474321 | — | — | 1 | 7.70 |
| CHEMBL4540223 | — | — | 1 | 7.70 |
| CHEMBL4462144 | — | — | 1 | 7.70 |
| CHEMBL4573074 | — | — | 1 | 7.70 |
| CHEMBL4552089 | — | — | 1 | 7.70 |
| CHEMBL4465054 | — | — | 1 | 7.70 |
| CHEMBL4438957 | — | — | 4 | 7.70 |
| CHEMBL4468010 | — | — | 1 | 7.70 |
| CHEMBL4526526 | — | — | 1 | 7.70 |
| CHEMBL4435159 | — | — | 1 | 7.52 |
| CHEMBL4539147 | — | — | 1 | 7.40 |
| CHEMBL4441395 | — | — | 1 | 7.40 |
| CHEMBL4517384 | — | — | 1 | 7.30 |
| CHEMBL4445083 | — | — | 1 | 7.30 |
| CHEMBL4566174 | — | — | 1 | 7.22 |
| CHEMBL4573882 | — | — | 1 | 7.22 |
| CHEMBL4439796 | — | — | 1 | 7.16 |
| CHEMBL4591097 | — | — | 1 | 6.96 |
| CHEMBL4449584 | — | — | 1 | 6.92 |
| CHEMBL4588248 | — | — | 1 | 6.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4466863 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4577528 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4570468 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4459563 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4578839 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4465054 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4468010 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4589856 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4476079 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4438957 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4446841 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4544112 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4465931 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4552089 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4573074 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4540223 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4526526 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4462144 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4474321 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4435159 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4438957 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4438957 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4539147 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4441395 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4517384 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4445083 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4566174 | — | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL4573882 | — | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL4439796 | — | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL4438957 | — | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL4591097 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4449584 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4588248 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4444544 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4566810 | — | EC50 | = | 230.0 | nM | 6.64 |
| CHEMBL1229884 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4465353 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4586305 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4566128 | — | EC50 | = | 320.0 | nM | 6.50 |
| CHEMBL4556336 | — | EC50 | = | 830.0 | nM | 6.08 |
| CHEMBL4553050 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL1231573 | — | EC50 | = | 4500.0 | nM | 5.35 |