Assay Detail
Binding
CHEMBL4338401
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activation of recombinant human STING haplotype R293Q mutant expressed in 293T cells measured after 30 mins in presence of digitonin A by bright Glo-luciferase reporter gene assay
42
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Stimulator of interferon genes protein (CHEMBL4523377) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Enzymatic Preparation of 2'-5',3'-5'-Cyclic Dinucleotides, Their Binding Properties to Stimulator of Interferon Genes Adaptor Protein, and Structure/Activity Correlations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 42 | 6.34 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4577528 | — | — | 1 | 7.70 |
| CHEMBL4552089 | — | — | 1 | 7.70 |
| CHEMBL4438957 | — | — | 4 | 7.52 |
| CHEMBL4589856 | — | — | 1 | 7.40 |
| CHEMBL4566174 | — | — | 1 | 7.40 |
| CHEMBL4465054 | — | — | 1 | 7.30 |
| CHEMBL4459563 | — | — | 1 | 7.22 |
| CHEMBL4446841 | — | — | 1 | 7.10 |
| CHEMBL4441395 | — | — | 1 | 7.05 |
| CHEMBL4570468 | — | — | 1 | 6.92 |
| CHEMBL4544112 | — | — | 1 | 6.89 |
| CHEMBL4573882 | — | — | 1 | 6.85 |
| CHEMBL4578839 | — | — | 1 | 6.80 |
| CHEMBL4435159 | — | — | 1 | 6.77 |
| CHEMBL4476079 | — | — | 1 | 6.75 |
| CHEMBL4468010 | — | — | 1 | 6.70 |
| CHEMBL4465931 | — | — | 1 | 6.62 |
| CHEMBL4540223 | — | — | 1 | 6.51 |
| CHEMBL4474321 | — | — | 1 | 6.47 |
| CHEMBL4444544 | — | — | 1 | 6.22 |
| CHEMBL4445083 | — | — | 1 | 6.16 |
| CHEMBL4462144 | — | — | 1 | 6.16 |
| CHEMBL4588248 | — | — | 1 | 6.14 |
| CHEMBL4573074 | — | — | 1 | 6.11 |
| CHEMBL4439796 | — | — | 1 | 6.02 |
| CHEMBL4539147 | — | — | 1 | 5.96 |
| CHEMBL4526526 | — | — | 1 | 5.92 |
| CHEMBL4466863 | — | — | 1 | 5.91 |
| CHEMBL4449584 | — | — | 1 | 5.69 |
| CHEMBL4517384 | — | — | 1 | 5.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4552089 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4577528 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4438957 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4589856 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4566174 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4465054 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4459563 | — | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL4438957 | — | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL4446841 | — | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL4438957 | — | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL4441395 | — | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL4570468 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4544112 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4573882 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4578839 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4435159 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL4476079 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL4438957 | — | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL4468010 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4465931 | — | EC50 | = | 240.0 | nM | 6.62 |
| CHEMBL4540223 | — | EC50 | = | 310.0 | nM | 6.51 |
| CHEMBL4474321 | — | EC50 | = | 340.0 | nM | 6.47 |
| CHEMBL4444544 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL4462144 | — | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL4445083 | — | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL4588248 | — | EC50 | = | 720.0 | nM | 6.14 |
| CHEMBL4573074 | — | EC50 | = | 780.0 | nM | 6.11 |
| CHEMBL4439796 | — | EC50 | = | 960.0 | nM | 6.02 |
| CHEMBL4539147 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4526526 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4466863 | — | EC50 | = | 1230.0 | nM | 5.91 |
| CHEMBL4449584 | — | EC50 | = | 2060.0 | nM | 5.69 |
| CHEMBL4517384 | — | EC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL4591097 | — | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL4566810 | — | EC50 | = | 5720.0 | nM | 5.24 |
| CHEMBL1229884 | — | EC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL4586305 | — | EC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL4465353 | — | EC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL4553050 | — | EC50 | = | 32800.0 | nM | 4.48 |
| CHEMBL4566128 | — | EC50 | = | 45300.0 | nM | 4.34 |
| CHEMBL4556336 | — | EC50 | = | 47200.0 | nM | 4.33 |
| CHEMBL1231573 | — | EC50 | > | 45000.0 | nM | - |