Assay Detail
Binding
CHEMBL4339329
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Inhibition of ovine COX -1 by colorimetric inhibitor screening assay kit method
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Ovis aries |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Tackling neuroinflammation and cholinergic deficit in Alzheimer's disease: Multi-target inhibitors of cholinesterases, cyclooxygenase-2 and 15-lipoxygenase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.29 | 7.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | 7.41 |
| CHEMBL139 | DICLOFENAC | 4.0 | 1 | 5.41 |
| CHEMBL4458648 | — | — | 1 | 5.08 |
| CHEMBL4592037 | — | — | 1 | 4.96 |
| CHEMBL4553902 | — | — | 1 | 4.91 |
| CHEMBL4443988 | — | — | 1 | 4.87 |
| CHEMBL4526428 | — | — | 1 | 4.86 |
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 4.83 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6 | INDOMETHACIN | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL139 | DICLOFENAC | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL4458648 | — | IC50 | = | 8330.0 | nM | 5.08 |
| CHEMBL4592037 | — | IC50 | = | 10900.0 | nM | 4.96 |
| CHEMBL4553902 | — | IC50 | = | 12200.0 | nM | 4.91 |
| CHEMBL4443988 | — | IC50 | = | 13400.0 | nM | 4.87 |
| CHEMBL4526428 | — | IC50 | = | 13900.0 | nM | 4.86 |
| CHEMBL118 | CELECOXIB | IC50 | = | 14800.0 | nM | 4.83 |