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Assay Detail

CHEMBL4339658

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Inhibition of CYP1A2 in human liver microsomes
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Homo sapiens
Tissue Liver
Subcellular Microsomes
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Cytochrome P450 1A2 (CHEMBL3356)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

1H-Pyrrolo[3,2-b]pyridine GluN2B-Selective Negative Allosteric Modulators.
Chrovian CC, Soyode-Johnson A, Wall JL, Rech JC, Schoellerman J, Lord B, Coe KJ, Carruthers NI, Nguyen L, Jiang X, Koudriakova T, Balana B, Letavic MA.
ACS Med Chem Lett (2019) 10 : 261 -266
PubMed 30891123 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 5.89 6.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4537967 1 6.40
CHEMBL4446706 1 6.05
CHEMBL4471014 1 5.92
CHEMBL4526512 1 5.82
CHEMBL4539619 1 5.24
CHEMBL4302264 1 -
CHEMBL4590530 1 -
CHEMBL4571666 1 -
CHEMBL4443868 1 -
CHEMBL4451099 1 -
CHEMBL4474982 1 -
CHEMBL4593473 1 -
CHEMBL4547576 1 -
CHEMBL4591770 1 -
CHEMBL4531750 1 -
CHEMBL4575739 1 -
CHEMBL4529810 1 -
CHEMBL4211247 1 -
CHEMBL4462073 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4537967 IC50 = 400.0 nM 6.40
CHEMBL4446706 IC50 = 900.0 nM 6.05
CHEMBL4471014 IC50 = 1200.0 nM 5.92
CHEMBL4526512 IC50 = 1500.0 nM 5.82
CHEMBL4539619 IC50 = 5700.0 nM 5.24
CHEMBL4302264 IC50 > 10000.0 nM -
CHEMBL4590530 IC50 > 10000.0 nM -
CHEMBL4571666 IC50 > 10000.0 nM -
CHEMBL4443868 IC50 > 10000.0 nM -
CHEMBL4451099 IC50 > 10000.0 nM -
CHEMBL4474982 IC50 > 10000.0 nM -
CHEMBL4593473 IC50 > 10000.0 nM -
CHEMBL4547576 IC50 > 10000.0 nM -
CHEMBL4591770 IC50 > 10000.0 nM -
CHEMBL4531750 IC50 > 10000.0 nM -
CHEMBL4575739 IC50 > 10000.0 nM -
CHEMBL4529810 IC50 > 10000.0 nM -
CHEMBL4211247 IC50 > 10000.0 nM -
CHEMBL4462073 IC50 > 10000.0 nM -