Assay Detail
ADMET
CHEMBL4339659
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Inhibition of CYP2C19 in human liver microsomes
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Tissue | Liver |
| Subcellular | Microsomes |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
1H-Pyrrolo[3,2-b]pyridine GluN2B-Selective Negative Allosteric Modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 5.53 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4537967 | — | — | 1 | 6.52 |
| CHEMBL4526512 | — | — | 1 | 6.22 |
| CHEMBL4446706 | — | — | 1 | 5.60 |
| CHEMBL4539619 | — | — | 1 | 5.33 |
| CHEMBL4471014 | — | — | 1 | 5.31 |
| CHEMBL4475155 | — | — | 1 | 5.12 |
| CHEMBL4550955 | — | — | 1 | 5.09 |
| CHEMBL4529074 | — | — | 1 | 5.08 |
| CHEMBL4443868 | — | — | 1 | - |
| CHEMBL4211247 | — | — | 1 | - |
| CHEMBL4529810 | — | — | 1 | - |
| CHEMBL4575739 | — | — | 1 | - |
| CHEMBL4531750 | — | — | 1 | - |
| CHEMBL4591770 | — | — | 1 | - |
| CHEMBL4547576 | — | — | 1 | - |
| CHEMBL4593473 | — | — | 1 | - |
| CHEMBL4474982 | — | — | 1 | - |
| CHEMBL4451099 | — | — | 1 | - |
| CHEMBL4462073 | — | — | 1 | - |
| CHEMBL4571666 | — | — | 1 | - |
| CHEMBL4302264 | — | — | 1 | - |
| CHEMBL4590530 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4537967 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4526512 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL4446706 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL4539619 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL4471014 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL4475155 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL4550955 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL4529074 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL4443868 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4211247 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4529810 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4575739 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4531750 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4591770 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4547576 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4593473 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4474982 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4451099 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4462073 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4571666 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4302264 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4590530 | — | IC50 | > | 10000.0 | nM | - |