Assay Detail
Functional
CHEMBL4341983
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Antiproliferative activity against human Jurkat cells assessed as reduction in cell growth incubated for 48 hrs by MTT assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Jurkat |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and preliminary bioactivity studies of indomethacin derivatives as Bcl-2/Mcl-1 dual inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.41 | 4.61 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4439398 | — | — | 1 | 4.61 |
| CHEMBL4482922 | — | — | 1 | 4.52 |
| CHEMBL3401826 | — | — | 1 | 4.50 |
| CHEMBL4515351 | — | — | 1 | 4.47 |
| CHEMBL4528136 | — | — | 1 | 4.45 |
| CHEMBL4544703 | — | — | 1 | 4.26 |
| CHEMBL4439691 | — | — | 1 | 4.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4439398 | — | IC50 | = | 24690.0 | nM | 4.61 |
| CHEMBL4482922 | — | IC50 | = | 30320.0 | nM | 4.52 |
| CHEMBL3401826 | — | IC50 | = | 31840.0 | nM | 4.50 |
| CHEMBL4515351 | — | IC50 | = | 33980.0 | nM | 4.47 |
| CHEMBL4528136 | — | IC50 | = | 35920.0 | nM | 4.45 |
| CHEMBL4544703 | — | IC50 | = | 55250.0 | nM | 4.26 |
| CHEMBL4439691 | — | IC50 | = | 83480.0 | nM | 4.08 |