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Assay Detail

CHEMBL4343685

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antitrypanosomal activity against Trypanosoma cruzi Tulahuen C4 trypomastigotes infected in rat L6 cells measured after 96 hrs by inverted microscopy analysis
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Trypanosoma cruzi
Confidence 1 — Organism
Curated By Autocuration

Target

Trypanosoma cruzi (CHEMBL368)
Type ORGANISM
Organism Trypanosoma cruzi

Publication

A new chemotype with promise against Trypanosoma cruzi.
Wang X, Cal M, Kaiser M, Buckner FS, Lepesheva GI, Sanford AG, Wallick AI, Davis PH, Vennerstrom JL.
Bioorg Med Chem Lett (2020) 30 : 126778 -126778
PubMed 31706668 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 4.91 8.15

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3105168 1 8.15
CHEMBL4589398 1 5.92
CHEMBL4564866 1 5.68
CHEMBL4455431 1 5.08
CHEMBL4540451 1 4.77
CHEMBL4580352 1 4.55
CHEMBL4516458 1 4.34
CHEMBL4448813 1 4.19
CHEMBL4548849 1 4.16
CHEMBL4575479 1 4.06
CHEMBL4470169 1 4.02
CHEMBL4455659 1 4.00
CHEMBL4519951 1 -
CHEMBL4533638 1 -
CHEMBL4537131 1 -
CHEMBL4475807 1 -
CHEMBL4584246 1 -
CHEMBL4446989 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3105168 IC50 = 7.0 nM 8.15
CHEMBL4589398 IC50 = 1200.0 nM 5.92
CHEMBL4564866 IC50 = 2100.0 nM 5.68
CHEMBL4455431 IC50 = 8300.0 nM 5.08
CHEMBL4540451 IC50 = 17000.0 nM 4.77
CHEMBL4580352 IC50 = 28000.0 nM 4.55
CHEMBL4516458 IC50 = 46000.0 nM 4.34
CHEMBL4448813 IC50 = 65000.0 nM 4.19
CHEMBL4548849 IC50 = 69000.0 nM 4.16
CHEMBL4575479 IC50 = 88000.0 nM 4.06
CHEMBL4470169 IC50 = 96000.0 nM 4.02
CHEMBL4455659 IC50 = 100000.0 nM 4.00
CHEMBL4519951 IC50 = 120000.0 nM -
CHEMBL4533638 IC50 = 110000.0 nM -
CHEMBL4537131 IC50 = 130000.0 nM -
CHEMBL4475807 IC50 = 110000.0 nM -
CHEMBL4584246 IC50 = 120000.0 nM -
CHEMBL4446989 IC50 = 120000.0 nM -