Assay Detail
Binding
CHEMBL4343754
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Agonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as beta-arrestin 2 recruitment measured after 90 mins by beta-galactosidase based PathHunter assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
An Agonist Radioligand for the Proinflammatory Lipid-Activated G Protein-Coupled Receptor GPR84 Providing Structural Insights.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 13 | 5.70 | 6.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4456892 | — | — | 1 | 6.37 |
| CHEMBL1232858 | — | — | 1 | 6.34 |
| CHEMBL4538049 | — | — | 1 | 6.28 |
| CHEMBL107874 | TRIDECANOATE | 2.0 | 1 | 5.77 |
| CHEMBL4288936 | — | — | 1 | 5.49 |
| CHEMBL108766 | DODECANOATE | — | 1 | 5.46 |
| CHEMBL4448230 | — | — | 1 | 5.39 |
| CHEMBL108030 | UNDECANOATE | 3.0 | 1 | 5.36 |
| CHEMBL2004471 | — | — | 1 | 5.36 |
| CHEMBL111077 | MYRISTIC ACID | -1.0 | 1 | 5.15 |
| CHEMBL324846 | OCTANOIC ACID | 2.0 | 1 | - |
| CHEMBL4447980 | — | — | 1 | - |
| CHEMBL55068 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4456892 | — | EC50 | = | 432.0 | nM | 6.37 |
| CHEMBL1232858 | — | EC50 | = | 452.0 | nM | 6.34 |
| CHEMBL4538049 | — | EC50 | = | 522.0 | nM | 6.28 |
| CHEMBL107874 | TRIDECANOATE | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL4288936 | — | EC50 | = | 3250.0 | nM | 5.49 |
| CHEMBL108766 | DODECANOATE | EC50 | = | 3490.0 | nM | 5.46 |
| CHEMBL4448230 | — | EC50 | = | 4050.0 | nM | 5.39 |
| CHEMBL108030 | UNDECANOATE | EC50 | = | 4360.0 | nM | 5.36 |
| CHEMBL2004471 | — | EC50 | = | 4360.0 | nM | 5.36 |
| CHEMBL111077 | MYRISTIC ACID | EC50 | = | 7010.0 | nM | 5.15 |
| CHEMBL324846 | OCTANOIC ACID | EC50 | > | 100000.0 | nM | - |
| CHEMBL4447980 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL55068 | — | EC50 | > | 100000.0 | nM | - |