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Compound Detail

CHEMBL108766

DODECANOATE
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CCCCCCCCCCCC(=O)O

Basic Information

ChEMBL ID CHEMBL108766
Name DODECANOATE
Phase Preclinical
Structure Type MOL
InChI Key POULHZVOKOAJMA-UHFFFAOYSA-N
6
Targets
16
Activities
3
Assay Types
0
PK Parameters
20
Publications
0
Known Names

Molecular Properties

200.3
MW (Da)
3.99
ALogP
1
HBA
1
HBD
37.3
PSA (Ų)
0.54
QED
0
Ro5 Violations
10
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C12H24O2
MW 200.32
Aromatic Rings 0
Heavy Atoms 14
NP-Likeness 0.50

Activity Summary

EC50 10 meas. best 6.12
IC50 5 meas. best 4.52
Ki 1 meas. best 5.66

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Free fatty acid receptor 1
CHEMBL4422
EC50 6.12 5.3867 758.6 3
G-protein coupled receptor 84
CHEMBL3714079
Ki 5.66 5.66 2170.0 1
G-protein coupled receptor 84
CHEMBL3714079
EC50 5.46 5.0983 3490.0 6
Free fatty acid receptor 4
CHEMBL5339
EC50 5.12 5.12 7585.8 1
Peroxisome proliferator-activated receptor gamma
CHEMBL235
IC50 4.52 4.52 30000.0 1
Peroxisome proliferator-activated receptor alpha
CHEMBL239
IC50 4.52 4.52 30000.0 1
Peroxisome proliferator-activated receptor delta
CHEMBL3979
IC50 4.52 4.52 30000.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Free fatty acid receptor 1 EC50 = 758.58 nM 6.12 Agonist activity at FFA1 receptor (unknown origin) expressed in human 132N1 cell... 27074625
G-protein coupled receptor 84 Ki = 2170.0 nM 5.66 Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell ... 31721581
G-protein coupled receptor 84 EC50 = 3490.0 nM 5.46 Agonist activity at recombinant human GPR84 expressed in CHO cell membranes co-e... 31721581
Free fatty acid receptor 4 EC50 = 7585.78 nM 5.12 Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA4 rece... 30108848
Free fatty acid receptor 1 EC50 = 7943.28 nM 5.1 Agonist activity at human C-terminal eYFP-tagged FFA1 receptor expressed in HEK-... 27074625
G-protein coupled receptor 84 EC50 = 8709.64 nM 5.06 Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human GPR84 exp... 30108848
G-protein coupled receptor 84 EC50 = 8800.0 nM 5.06 Agonist activity at human GPR84 expressed in CHO cells assessed as reduction in ... 33267584
G-protein coupled receptor 84 EC50 = 8870.0 nM 5.05 Agonist activity at recombinant human GPR84 expressed in CHO cell membranes co-e... 31721581
G-protein coupled receptor 84 EC50 = 10471.29 nM 4.98 Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human GPR84 exp... 30108848
G-protein coupled receptor 84 EC50 = 10500.0 nM 4.98 Agonist activity at human GPR84 expressed in CHO cell membranes assessed as indu... 33267584
Free fatty acid receptor 1 EC50 = 11481.54 nM 4.94 Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA1 rece... 30108848
Peroxisome proliferator-activated receptor delta IC50 = 30000.0 nM 4.52 Displacement of [3H]GW2433 from Homo sapiens (human) PPARdelta receptor by scint... -
Peroxisome proliferator-activated receptor gamma IC50 = 30000.0 nM 4.52 Displacement of [3H]BRL49653 from Homo sapiens (human) PPARgamma receptor by sci... -
Peroxisome proliferator-activated receptor alpha IC50 = 30000.0 nM 4.52 Displacement of [3H]GW2331 from Homo sapiens (human) PPARalpha receptor by scint... -

Literature References

PubMed DOI Target Context # Activities
23121218 10.1021/jf3036885 Meloidogyne incognita 18
27074625 10.1021/acs.jmedchem.6b00202 Free fatty acid receptor 1 5
31721581 10.1021/acs.jmedchem.9b01339 G-protein coupled receptor 84 5
21903399 10.1016/j.bmc.2011.08.023 Unchecked 4
- 10.6019/CHEMBL4495565 SARS-CoV-2 4
6802973 10.1021/jm00345a016 No relevant target 3
21903399 10.1016/j.bmc.2011.08.023 RAW264.7 3
30108848 10.1039/C7MD00130D G-protein coupled receptor 84 3
- 10.6019/CHEMBL4808148 Histone deacetylase 6 2
21493076 10.1016/j.bmc.2011.03.036 Staphylococcus aureus 2
18778047 10.1021/jm800345u Staphylococcus aureus 2
21903399 10.1016/j.bmc.2011.08.023 DNA polymerase lambda 2
33267584 10.1021/acs.jmedchem.0c01378 G-protein coupled receptor 84 2
- 10.6019/CHEMBL4495564 Replicase polyprotein 1ab 2
- 10.6019/CHEMBL4651402 SARS-CoV-2 2
21903399 10.1016/j.bmc.2011.08.023 DNA polymerase kappa 2
6802973 10.1021/jm00345a016 Bacillus subtilis 2
1517735 10.1021/np50083a010 Klebsiella aerogenes 1
1517735 10.1021/np50083a010 Pseudomonas aeruginosa 1
7381846 10.1021/jm00179a001 Streptococcus pyogenes 1

Data from ChEMBL 36 via Core Engine